Evidence map›Paper›PMID 28664154›Full record

ArticleFrontiers in cellular and infection microbiology2017

Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus.

Chengmin Wang, Pengpeng Liu, Jing Luo, Hua Ding, Yan Gao, Lei Sun, Fubing Luo, Xiaodong Liu, Hongxuan He

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Genetic determinants of ammonia-induced acute lung injury in mice.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  8. Article
  9. Network-Based Analysis of Fatal Comorbidities of COVID-19 and Potential Therapeutics.IEEE/ACM transactions on computational biology and bioinformatics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Chengmin WangNational Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of SciencesBeijing, China.
Pengpeng LiuNational Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of SciencesBeijing, China.
Jing LuoNational Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of SciencesBeijing, China.
Hua DingDepartment of Infectious Diseases, Hangzhou Center for Disease Control and PreventionHangzhou, China.
Yan GaoDepartment of Infectious Diseases, Peking University People's HospitalBeijing, China.
Lei SunDepartment of Microbiology, Tumor and Cell Biology, Karolinska InstitutetStockholm, Sweden.
Fubing LuoBeijing Center for Animal Disease ControlBeijing, China.
Xiaodong LiuBeijing Center for Animal Disease ControlBeijing, China.
Hongxuan HeNational Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of SciencesBeijing, China.
Chinese Academy of Sciences · CNChina Animal Disease Control Center · CNHangzhou Center for Disease Control and Prevention · CNInstitute of Zoology · CNKarolinska Institutet · SEPeking University People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections with lethal influenza viruses lead to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), which may be related to the activation of the host's immune system. Here, in our study, male C57BL/6 mice were infected with 10 LD

Indexed as

Acute Lung InjuryAnimalsAntibodies, NeutralizingBenzoquinonesBronchoalveolar Lavage FluidChemokinesCytokinesHumansInfluenza A Virus, H5N1 SubtypeKiller Cells, NaturalLactams, MacrocyclicLethal Dose 50LungMacrophagesMaleMiceAntibodies, NeutralizingBenzoquinonesChemokinesCytokinesgeldanamycinLactams, MacrocyclicNP protein, Influenza A virusNucleocapsid ProteinsRNA-Binding ProteinsViral Core ProteinsALI/ARDSgeldanamycinH5N1survivalviral load

Identifiers

PMID28664154
PMCPMC5471324
OpenAlexW2697543105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.