ArticleIntegrative medicine research2017
Energy metabolism and whole-exome sequencing-based analysis of Sasang constitution: a pilot study.
Article in Integrative medicine research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Preliminary study on genetic factors related to Demirjian's tooth age estimation method based on genome-wide association analysis.International journal of legal medicine · 2023Article
- Perception on genetic testing in Korean medicine doctors: A mobile-based survey.Integrative medicine research · 2021Article
- Comparative gut microbiome analysis of the3 Biotech · 2020Article
- Pulmonary Function Difference in Sasang Constitutional Types.Evidence-based complementary and alternative medicine : eCAM · 2018Article
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8 authors.
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Abstract
backgroundTraditional Korean Sasang constitutional (SC) medicine categorizes individuals into four constitutional types [Tae-eum (TE), So-eum (SE), Tae-yang (TY), or So-yang (SY)] based on biological and physiological characteristics. As these characteristics are closely related to the bioenergetics of the human body, we assessed the correlation between SC type and energy metabolism features.
methodsForty healthy, young (22.3 ± 1.4 years) males volunteered to participate in this study. Participants answered an SC questionnaire, and their face shape, voice tone, and body shape were assessed using an SC analysis tool. Thirty-one participants (10 TE, 10 SE, 3 TY, and 8 SY) were selected for further analysis. Collected blood samples were subjected to blood composition analysis, mitochondrial function analysis, and whole-exome sequencing.
resultsThe SY type showed significantly lower total cholesterol and high-density lipoprotein cholesterol levels than the SE type. Cellular and mitochondrial Adenosine triphosphate (ATP) levels were similar across types. All types showed similar basal mitochondrial oxygen consumption rates, whereas the TE type showed a significantly lower ATP-linked oxygen consumption rate than the other types. Whole-exome sequencing identified several genes variants that were exclusively detected in particular SC types, including 19 for SE, seven for SY, 11 for TE, and six for TY.
conclusionSC type-specific differences in mitochondrial function and gene mutations were detected in a small group of healthy, young Korean males. These results are expected to greatly improve the accurate screening and utilization of SC medicine.
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