Evidence map›Paper›PMID 28663929›Full record

ArticleBiomedical optics express2017

Noninvasive depth estimation using tissue optical properties and a dual-wavelength fluorescent molecular probe

Jessica P Miller, Dolonchampa Maji, Jesse Lam, Bruce J Tromberg, Samuel Achilefu

Abstract read
In one paragraph

Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  8. Characterization of focused ultrasound-mediated brainstem delivery of intranasally administered agents.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Recent methodology advances in fluorescence molecular tomography.Visual computing for industry, biomedicine, and art · 2018
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica P MillerOptical Radiology Lab, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4515 McKinley Ave, St. Louis, Missouri 63110, USA.
Dolonchampa MajiOptical Radiology Lab, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4515 McKinley Ave, St. Louis, Missouri 63110, USA.
Jesse LamLaser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA.
Bruce J TrombergLaser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA.
Samuel AchilefuOptical Radiology Lab, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4515 McKinley Ave, St. Louis, Missouri 63110, USA.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU-MDACC Inter-Institutional Molecular Imaging CenterP50CA094056 · NCI · WASHINGTON UNIVERSITY · PI KOPAN, RAPHAEL · 2002 to 2016
$26.3M
DEVELOPMENT OF GOGGLE SYSTEM FOR FLUORESCENCE IMAGE-GUIDED SURGERYR01CA171651 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2013 to 2017
$2.8M
MOLECULAR PROBES AND METHODS FOR FLUORESCENCE LIFETIME TOMOGRAPHY AND MICROSCOPYR01EB008111 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2009 to 2012
$1.9M
FLUORESCENCE MOLECULAR TOMOGRAPHY SYSTEMS10OD020129 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2015
$330k
NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA094056NCI NIH HHS R01 CA171651NIBIB NIH HHS R01 EB008111NIH HHS S10 OD020129
6 · The paper itself

Abstract

Translation of fluorescence imaging using molecularly targeted imaging agents for real-time assessment of surgical margins in the operating room requires a fast and reliable method to predict tumor depth from planar optical imaging. Here, we developed a dual-wavelength fluorescent molecular probe with distinct visible and near-infrared excitation and emission spectra for depth estimation in mice and a method to predict the optical properties of the imaging medium such that the technique is applicable to a range of medium types. Imaging was conducted at two wavelengths in a simulated blood vessel and an

Indexed as

(170.0170) Medical optics and biotechnology(170.3880) Medical and biological imaging

Identifiers

PMID28663929
PMCPMC5480452

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.