ArticleBiomedical optics express2017
Quantitative interferometric reflectance imaging for the detection and measurement of biological nanoparticles.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Exosomes orchestrate immune homeostasis in acute ischemia-reperfusion flap injury and chronic wounds: the TLR4/NF-κB-STAT3 R-ratio balance decision model, engineering optimization and translational clinical strategy.Frontiers in immunology · 2026Pooled it
- Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Investigation of optical properties of three dimensional reflectance rulers fabricated by size-controlled monodisperse polystyrene colloidal particles.Scientific reports · 2025Article
- Multimodal Biosensing of Foodborne Pathogens.International journal of molecular sciences · 2024Review
- Single virus fingerprinting by widefield interferometric defocus-enhanced mid-infrared photothermal microscopy.Nature communications · 2023Article
- Background-Suppressed High-Throughput Mid-Infrared Photothermal Microscopy via Pupil Engineering.ACS photonics · 2021Article
- Scattering-based Light Microscopy: From Metal Nanoparticles to Single Proteins.Chemical reviews · 2021Review
- Label-Free and Quantitative Dry Mass Monitoring for Single Cells during In Situ Culture.Cells · 2021Article
- Vibrational Spectroscopic Detection of a Single Virus by Mid-Infrared Photothermal Microscopy.Analytical chemistry · 2021Article
- Engineering photonics solutions for COVID-19.APL photonics · 2020Review
- High-Throughput, High-Resolution Interferometric Light Microscopy of Biological Nanoparticles.ACS nano · 2020Article
- Quantitative Measurement of the Optical Cross Sections of Single Nano-objects by Correlative Transmission and Scattering Microspectroscopy.ACS photonics · 2019Article
- Interferometric Scattering Microscopy: Seeing Single Nanoparticles and Molecules via Rayleigh Scattering.Nano letters · 2019Article
- Label-free detection of nanoparticles using depth scanning correlation interferometric microscopy.Scientific reports · 2019Article
- Label-free tomography of living cellular nanoarchitecture using hyperspectral self-interference microscopy.Biomedical optics express · 2019Article
- Beating the reaction limits of biosensor sensitivity with dynamic tracking of single binding events.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The sensitive detection and quantitative measurement of biological nanoparticles such as viruses or exosomes is of growing importance in biology and medicine since these structures are implicated in many biological processes and diseases. Interferometric reflectance imaging is a label-free optical biosensing method which can directly detect individual biological nanoparticles when they are immobilized onto a protein microarray. Previous efforts to infer bio-nanoparticle size and shape have relied on empirical calibration using a 'ruler' of particle samples of known size, which was inconsistent and qualitative. Here, we present a mechanistic physical explanation and experimental approach by which interferometric reflectance imaging may be used to not only detect but also quantitatively measure bio-nanoparticle size and shape. We introduce a comprehensive optical model that can quantitatively simulate the scattering of arbitrarily-shaped nanoparticles such as rod-shaped or filamentous virions. Finally, we optimize the optical design for the detection and quantitative measurement of small and low-index bio-nanoparticles immersed in water.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.