ArticleBiomedical optics express2017
Structured illumination multimodal 3D-resolved quantitative phase and fluorescence sub-diffraction microscopy.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- A correlative quantitative phase contrast and fluorescence super-resolution microscope for imaging molecules in their cellular context.bioRxiv : the preprint server for biology · 2025Article
- Label-free refractive index mapping of human sperm cells.Biomedical optics express · 2025Article
- Imaging 3D cell cultures with optical microscopy.Nature methods · 2025Review
- Characterization of a Single-Capture Bright-Field and Off-Axis Digital Holographic Microscope for Biological Applications.Sensors (Basel, Switzerland) · 2025Article
- Review
- Recover Biological Structure from Sparse-View Diffraction Images with Neural Volumetric Prior.Proceedings. IEEE International Conference on Computer Vision · 2025Article
- Surpassing the Diffraction Limit in Label-Free Optical Microscopy.ACS photonics · 2024Review
- Quantitative phase imaging based on holography: trends and new perspectives.Light, science & applications · 2024Review
- Single-shot quantitative phase-fluorescence imaging using cross-grating wavefront microscopy.Scientific reports · 2024Article
- Polarization differential interference contrast microscopy with physics-inspired plug-and-play denoiser for single-shot high-performance quantitative phase imaging.Biomedical optics express · 2023Article
- Fluholoscopy-Compact and Simple Platform Combining Fluorescence and Holographic Microscopy.Biosensors · 2023Article
- Review
- Multimodal on-chip nanoscopy and quantitative phase imaging reveals the nanoscale morphology of liver sinusoidal endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Common-path intrinsically achromatic optical diffraction tomography.Biomedical optics express · 2021Article
- Label-Free and Quantitative Dry Mass Monitoring for Single Cells during In Situ Culture.Cells · 2021Article
- Limited-angle tomographic phase microscopy utilizing confocal scanning fluorescence microscopy.Biomedical optics express · 2021Article
- Holotomography: Refractive Index as an Intrinsic Imaging Contrast for 3-D Label-Free Live Cell Imaging.Advances in experimental medicine and biology · 2021Article
- Digital Holographic Multimodal Cross-Sectional Fluorescence and Quantitative Phase Imaging System.Scientific reports · 2020Article
- Common-path multimodal three-dimensional fluorescence and phase imaging system.Journal of biomedical optics · 2020Article
- Shear Modulus Measurement by Quantitative Phase Imaging and Correlation with Atomic Force Microscopy.Biophysical journal · 2019Article
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Authors and funding
4 authors.
Funding
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Abstract
Sub-diffraction resolution imaging has played a pivotal role in biological research by visualizing key, but previously unresolvable, sub-cellular structures. Unfortunately, applications of far-field sub-diffraction resolution are currently divided between fluorescent and coherent-diffraction regimes, and a multimodal sub-diffraction technique that bridges this gap has not yet been demonstrated. Here we report that structured illumination (SI) allows multimodal sub-diffraction imaging of both coherent quantitative-phase (QP) and fluorescence. Due to SI's conventionally fluorescent applications, we first demonstrate the principle of SI-enabled three-dimensional (3D) QP sub-diffraction imaging with calibration microspheres. Image analysis confirmed enhanced lateral and axial resolutions over diffraction-limited QP imaging, and established striking parallels between coherent SI and conventional optical diffraction tomography. We next introduce an optical system utilizing SI to achieve 3D sub-diffraction, multimodal QP/fluorescent visualization of A549 biological cells fluorescently tagged for F-actin. Our results suggest that SI has a unique utility in studying biological phenomena with significant molecular, biophysical, and biochemical components.
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