Evidence map›Paper›PMID 28663855›Full record

ArticleBiomedical optics express2017

Simulation of nanoparticle-mediated near-infrared thermal therapy using GATE.

Vesna Cuplov, Frédéric Pain, Sébastien Jan

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Vesna CuplovIMIV, CEA, Inserm, Université Paris Sud, CNRS, CEA/Service Hospitalier Frédéric Joliot, F-91401, Orsay, France.
Frédéric PainIMNC, CNRS, Université Paris Sud, Université Paris Saclay, F-91405, Orsay, France.
Sébastien JanIMIV, CEA, Inserm, Université Paris Sud, CNRS, CEA/Service Hospitalier Frédéric Joliot, F-91401, Orsay, France.
Commissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInstitut d'Imagerie Biomédicale · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Application of nanotechnology for biomedicine in cancer therapy allows for direct delivery of anticancer agents to tumors. An example of such therapies is the nanoparticle-mediated near-infrared hyperthermia treatment. In order to investigate the influence of nanoparticle properties on the spatial distribution of heat in the tumor and healthy tissues, accurate simulations are required. The Geant4 Application for Emission Tomography (GATE) open-source simulation platform, based on the Geant4 toolkit, is widely used by the research community involved in molecular imaging, radiotherapy and optical imaging. We present an extension of GATE that can model nanoparticle-mediated hyperthermal therapy as well as simple heat diffusion in biological tissues. This new feature of GATE combined with optical imaging allows for the simulation of a theranostic scenario in which the patient is injected with theranostic nanosystems that can simultaneously deliver therapeutic (i.e. hyperthermia therapy) and imaging agents (i.e. fluorescence imaging).

Indexed as

(160.0160) Materials(160.4236) Nanomaterials(170.0170) Medical optics and biotechnology(170.3660) Light propagation in tissues(170.4580) Optical diagnostics for medicine(350.0350) Other areas of optics(350.5340) Photothermal effects

Identifiers

PMID28663855
PMCPMC5480570
OpenAlexW2591212377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.