Scattering and absorption control in biocompatible fibers towards equalized photobiomodulation.

J George, H Haghshenas, D d'Hemecourt, W Zhu, L Zhang, V Sorger

Abstract read

In one paragraph

Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J GeorgeDepartment of Electrical and Computer Engineering, The George Washington University, Washington, D.C. 20052, USA.

H HaghshenasDepartment of Biomedical Engineering, The George Washington University, Washington, D.C. 20052, USA.

D d'HemecourtDepartment of Electrical and Computer Engineering, The George Washington University, Washington, D.C. 20052, USA.

W ZhuDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, D.C. 20052, USA.

L ZhangDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, D.C. 20052, USA.

V SorgerDepartment of Electrical and Computer Engineering, The George Washington University, Washington, D.C. 20052, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transparent tissue scaffolds enable illumination of growing tissue to accelerate cell proliferation and improve other cell functions through photobiomodulation. The biphasic dose response of cells exposed to photobiomodulating light dictates that the illumination be evenly distributed across the scaffold such that the cells are neither under nor over exposed to light. However, equalized illumination has not been sufficiently addressed. Here we analyze and experimentally demonstrate spatially equalizing illumination by three methods, namely: engineered surface scattering, reflection by a gold mirror, and traveling-waves in a ring mesh. Our results show that nearly equalized illumination is achievable by controlling the light scattering-to-loss ratio. This demonstration furthers opportunities for dose-optimized photobiomodulation in tissue regeneration.

Indexed as

(170.0170) Medical optics and biotechnology(170.2945) Illumination design(170.3660) Light propagation in tissues

Identifiers

PMID28663851

DOI10.1364/BOE.8.001589

PMCPMC5480566

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.