Evidence map›Paper›PMID 28663509›Full record

ArticleStroke2017

Physical Exercise Improves Cognitive Outcomes in 2 Models of Transient Cerebral Ischemia.

Holly M Stradecki-Cohan, Mehdi Youbi, Charles H Cohan, Isa Saul, Alexandra A Garvin, Edwin Perez, Kunjan R Dave, Clinton B Wright, Ralph L Sacco, Miguel A Perez-Pinzon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Post cardiac arrest physical exercise mitigates cell death in the septal and thalamic nuclei and ameliorates contextual fear conditioning deficits in rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  4. Poster Presentations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  5. Review
  6. Impacts of exercise intervention on various diseases in rats.Journal of sport and health science · 2020
    Review
  7. Article
  8. Poster Viewing Sessions PB01-B01 to PB03-V09.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Holly M Stradecki-CohanFrom the Department of Neurology, Cerebral Vascular Disease Research Laboratories (H.M.S.-C., M.Y., C.H.C., I.S., A.A.G., E.P., K.R.D., C.B.W., R.L.S., M.A.P.-P.); MD/PhD Program, (H.M.S.-C.); and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL (H.M.S.-C., K.R.D., M.A.P.-P.).
Mehdi YoubiFrom the Department of Neurology, Cerebral Vascular Disease Research Laboratories (H.M.S.-C., M.Y., C.H.C., I.S., A.A.G., E.P., K.R.D., C.B.W., R.L.S., M.A.P.-P.); MD/PhD Program, (H.M.S.-C.); and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL (H.M.S.-C., K.R.D., M.A.P.-P.).
Charles H CohanFrom the Department of Neurology, Cerebral Vascular Disease Research Laboratories (H.M.S.-C., M.Y., C.H.C., I.S., A.A.G., E.P., K.R.D., C.B.W., R.L.S., M.A.P.-P.); MD/PhD Program, (H.M.S.-C.); and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL (H.M.S.-C., K.R.D., M.A.P.-P.).
Isa SaulFrom the Department of Neurology, Cerebral Vascular Disease Research Laboratories (H.M.S.-C., M.Y., C.H.C., I.S., A.A.G., E.P., K.R.D., C.B.W., R.L.S., M.A.P.-P.); MD/PhD Program, (H.M.S.-C.); and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL (H.M.S.-C., K.R.D., M.A.P.-P.).
Alexandra A GarvinFrom the Department of Neurology, Cerebral Vascular Disease Research Laboratories (H.M.S.-C., M.Y., C.H.C., I.S., A.A.G., E.P., K.R.D., C.B.W., R.L.S., M.A.P.-P.); MD/PhD Program, (H.M.S.-C.); and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL (H.M.S.-C., K.R.D., M.A.P.-P.).
Edwin PerezFrom the Department of Neurology, Cerebral Vascular Disease Research Laboratories (H.M.S.-C., M.Y., C.H.C., I.S., A.A.G., E.P., K.R.D., C.B.W., R.L.S., M.A.P.-P.); MD/PhD Program, (H.M.S.-C.); and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL (H.M.S.-C., K.R.D., M.A.P.-P.).
Kunjan R DaveFrom the Department of Neurology, Cerebral Vascular Disease Research Laboratories (H.M.S.-C., M.Y., C.H.C., I.S., A.A.G., E.P., K.R.D., C.B.W., R.L.S., M.A.P.-P.); MD/PhD Program, (H.M.S.-C.); and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL (H.M.S.-C., K.R.D., M.A.P.-P.).
Clinton B WrightFrom the Department of Neurology, Cerebral Vascular Disease Research Laboratories (H.M.S.-C., M.Y., C.H.C., I.S., A.A.G., E.P., K.R.D., C.B.W., R.L.S., M.A.P.-P.); MD/PhD Program, (H.M.S.-C.); and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL (H.M.S.-C., K.R.D., M.A.P.-P.).
Ralph L SaccoFrom the Department of Neurology, Cerebral Vascular Disease Research Laboratories (H.M.S.-C., M.Y., C.H.C., I.S., A.A.G., E.P., K.R.D., C.B.W., R.L.S., M.A.P.-P.); MD/PhD Program, (H.M.S.-C.); and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL (H.M.S.-C., K.R.D., M.A.P.-P.).
Miguel A Perez-PinzonFrom the Department of Neurology, Cerebral Vascular Disease Research Laboratories (H.M.S.-C., M.Y., C.H.C., I.S., A.A.G., E.P., K.R.D., C.B.W., R.L.S., M.A.P.-P.); MD/PhD Program, (H.M.S.-C.); and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL (H.M.S.-C., K.R.D., M.A.P.-P.). perezpinzon@med.miami.edu.

Funding

ISCHEMIC PRECONDITIONING: MECHANISMS OF NEUROPROTECTIONR01NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MIGUEL A PEREZ-PINZON · 2003 to 2026
$6.7M
MECHANISMS OF NEUROPROTECTION AGAINST CARDIAC ARRESTR01NS045676 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2004 to 2024
$5.1M
NINDS NIH HHS R01 NS034773NINDS NIH HHS R01 NS045676
6 · The paper itself

Abstract

background and purposePreclinical studies suggest that exercise can enhance cognition after cerebral ischemia but often use long training regiments and test cognition during or acutely after training. The cognitive changes may result from enhanced physical fitness and may only provide acute benefit. We sought to determine whether a short period of exercise after cerebral ischemia could improve cognitive outcomes when measured days after completion of exercise training in 2 cerebral ischemia models.

methodsFocal or global cerebral ischemia was induced in Sprague-Dawley rats. Rats recovered (3-4 days) then were subject to no exercise (0 m/min), mild (6 m/min), moderate (10 m/min), or heavy (15-18 m/min) treadmill exercise (5-6 days). Cognition was tested 8 to 10 days after the last exercise session with hippocampal-dependent contextual fear conditioning.

resultsA short training period of moderate exercise enhanced cognitive function for a week after exercise completion in both models of cerebral ischemia.

conclusionsUtilization of this exercise paradigm can further the elucidation of exercise-mediated factors involved in cognitive recovery independent of changes in physical fitness.

Indexed as

Disease Models, AnimalAnimalsCognitionIschemic Attack, TransientMalePhysical Conditioning, AnimalRandom AllocationRatsRats, Sprague-Dawleybrain ischemiacognitionexercisefearstroke

Identifiers

PMID28663509
PMCPMC5656263

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.