Evidence map›Paper›PMID 28663494›Full record

ArticleScience (New York, N.Y.)2017

Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling.

Jay A Blundon, Noah C Roy, Brett J W Teubner, Jing Yu, Tae-Yeon Eom, K Jake Sample, Amar Pani, Richard J Smeyne, Seung Baek Han, Ryan A Kerekes and 5 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Synaptic plasticity in human thalamocortical assembloids.bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Article
  9. iScience · 2022
    Article
  10. Earliest Experience of a Relatively Rare Sound But Not a Frequent Sound Causes Long-Term Changes in the Adult Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  11. Review
  12. Article
  13. Modifying the Adult Rat Tonotopic Map with Sound Exposure Produces Frequency Discrimination Deficits That Are Recovered with Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  14. Article
  15. Cell type- and tissue-specific functions of ecto-5'-nucleotidase (CD73).American journal of physiology. Cell physiology · 2019
    Review
  16. Review
  17. Review
  18. Article
  19. Adenosine AAnatomical record (Hoboken, N.J. : 2007) · 2018
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Jay A BlundonDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-1090-1625
Noah C RoyDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-1094-3315
Brett J W TeubnerDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jing YuDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-4676-3746
Tae-Yeon EomDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-7049-9079
K Jake SampleDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-1571-8731
Amar PaniDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Richard J SmeyneDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-8459-5472
Seung Baek HanDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-9798-0679
Ryan A KerekesElectrical and Electronics Systems Research Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.ORCID 0000-0001-7199-811X
Derek C RoseElectrical and Electronics Systems Research Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.ORCID 0000-0002-5217-4374
Troy A HackettDepartment of Hearing and Speech Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.ORCID 0000-0003-1743-4975
Pradeep K VuppalaPreclinical Pharmacokinetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-7079-9688
Burgess B FreemanPreclinical Pharmacokinetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-2174-5119
Stanislav S ZakharenkoDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-8115-202X
St. Jude Children's Research Hospital · USOak Ridge National Laboratory · USVanderbilt University · US

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Synaptic mechanisms of auditory memoryR01DC012833 · NIDCD · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ZAKHARENKO, STANISLAV S · 2013 to 2022
$4.2M
Towards understanding cellular mechanisms of positive symptoms of schizophreniaR01MH097742 · NIMH · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ZAKHARENKO, STANISLAV S · 2013 to 2022
$4.1M
Identification of Cellular Phenotypes in the Auditory ForebrainR01DC015388 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HACKETT, TROY A. · 2016 to 2020
$1.7M
Towards understanding cellular mechanisms of positive symptoms of schizophreniaR56MH097742 · NIMH · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ZAKHARENKO, STANISLAV S · 2018 to 2018
$494k
GPU-Accelerated Parallel Computer for Drug Discovery ApplicationsS10OD020154 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2015 to 2015
$225k
NICHD NIH HHS U54 HD083211NIDCD NIH HHS R01 DC012833NIDCD NIH HHS R01 DC015388NIMH NIH HHS R01 MH097742NIMH NIH HHS R56 MH097742
6 · The paper itself

Abstract

Circuits in the auditory cortex are highly susceptible to acoustic influences during an early postnatal critical period. The auditory cortex selectively expands neural representations of enriched acoustic stimuli, a process important for human language acquisition. Adults lack this plasticity. Here we show in the murine auditory cortex that juvenile plasticity can be reestablished in adulthood if acoustic stimuli are paired with disruption of ecto-5'-nucleotidase-dependent adenosine production or A

Indexed as

Signal Transduction5'-NucleotidaseAdenosineAdenosine A1 Receptor AgonistsAdenosine A1 Receptor AntagonistsAnimalsAuditory CortexAuditory PerceptionGPI-Linked ProteinsMiceNeuronal PlasticityPiperidinesPyridazinesReceptor, Adenosine A1Thalamus2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-3(2H)-pyridazinone2-chloro-N(6)cyclopentyladenosine5'-NucleotidaseAdenosineAdenosine A1 Receptor AgonistsAdenosine A1 Receptor AntagonistsGPI-Linked ProteinsNt5e protein, mousePiperidinesPyridazinesReceptor, Adenosine A1

Identifiers

PMID28663494
PMCPMC5523828
OpenAlexW2725591498

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.