Evidence map›Paper›PMID 28663371›Full record

ArticleThe Journal of biological chemistry2017

Functional characterization of a constitutively active kinase variant of

Jan Petersen, Shin-Ichiro Inoue, Sharon M Kelly, Stuart Sullivan, Toshinori Kinoshita, John M Christie

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Hydraulic Activation of the AsLOV2 Photoreceptor.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. The continuing arc toward phototropic enlightenment.Journal of experimental botany · 2020
    Article
  8. Engineering the phototropin photocycle improves photoreceptor performance and plant biomass production.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. Article
  10. Article
  11. Growth-mediated plant movements: hidden in plain sight.Current opinion in plant biology · 2018
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jan PetersenFrom the Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Bower Building, Glasgow G12 8QQ, United Kingdom.
Shin-Ichiro Inouethe Division of Biological Science, Graduate School of Science and.
Sharon M KellyFrom the Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Bower Building, Glasgow G12 8QQ, United Kingdom.
Stuart SullivanFrom the Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Bower Building, Glasgow G12 8QQ, United Kingdom.
Toshinori Kinoshitathe Division of Biological Science, Graduate School of Science and.
John M ChristieFrom the Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Bower Building, Glasgow G12 8QQ, United Kingdom, john.christie@glasgow.ac.uk.
University of Glasgow · GBNagoya University · JP

Funding

Biotechnology and Biological Sciences Research Council BB/J016047/1Biotechnology and Biological Sciences Research Council BB/M002128/1
6 · The paper itself

Abstract

Phototropins (phots) are plasma membrane-associated serine/threonine kinases that coordinate a range of processes linked to optimizing photosynthetic efficiency in plants. These photoreceptors contain two light-, oxygen-, or voltage-sensing (LOV) domains within their N terminus, with each binding one molecule of flavin mononucleotide as a UV/blue light-absorbing chromophore. Although phots contain two LOV domains, light-induced activation of the C-terminal kinase domain and subsequent receptor autophosphorylation is controlled primarily by the A'α-LOV2-Jα photosensory module. Mutations that disrupt interactions between the LOV2 core and its flanking helical segments can uncouple this mode of light regulation. However, the impact of these mutations on phot function in

Indexed as

Protein Processing, Post-TranslationalAmino Acid SubstitutionArabidopsisArabidopsis ProteinsCircular DichroismDNA-Binding ProteinsEnzyme ActivationEnzyme StabilityGreen Fluorescent ProteinsIsoenzymesLightPhosphoproteinsPhosphorylationPhotochemical ProcessesPhototropismPlants, Genetically ModifiedArabidopsis ProteinsDNA-Binding ProteinsGreen Fluorescent ProteinsIsoenzymesLOV2 protein, ArabidopsisNPH1 protein, ArabidopsisPhosphoproteinsProtein Serine-Threonine KinasesRecombinant Fusion ProteinsArabidopsis thalianaATPautophosphorylationA'α-helixflavin mononucleotide (FMN)LOV domainphototropinserine/threonine protein kinase

Identifiers

PMID28663371
PMCPMC5566536
OpenAlexW2727339977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.