Evidence map›Paper›PMID 28663369›Full record

ArticleThe Journal of biological chemistry2017

Structure-function analyses of a pertussis-like toxin from pathogenic

Dene R Littler, Sheng Y Ang, Danilo G Moriel, Martina Kocan, Oded Kleifeld, Matthew D Johnson, Mai T Tran, Adrienne W Paton, James C Paton, Roger J Summers and 3 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Cholera toxin as a model ABArchives of toxicology · 2026
    Review
  3. Article
  4. Nurr1 Orchestrates Claustrum Development and Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. The diverse landscape of AB5-type toxins.Engineering microbiology · 2023
    Review
  10. Article
  11. Article
  12. Sialoglycan-binding patterns of bacterial ABThe Journal of biological chemistry · 2022
    Article
  13. Crystal structures of pertussis toxin with NADThe Journal of biological chemistry · 2022
    Article
  14. Article
  15. Article
  16. ABToxins · 2022
    Review
  17. Article
  18. Cellular Activity ofToxins · 2021
    Article
  19. Review
  20. ADP-ribosylation systems in bacteria and viruses.Computational and structural biotechnology journal · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Dene R LittlerFrom the Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
Sheng Y Angthe Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Danilo G Morielthe School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.
Martina Kocanthe Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Oded Kleifeldthe Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Matthew D JohnsonFrom the Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
Mai T TranFrom the Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
Adrienne W Patonthe Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, South Australia 5005, Australia.
James C Patonthe Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, South Australia 5005, Australia.
Roger J Summersthe Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Mark A Schembrithe School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.
Jamie RossjohnFrom the Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia, jamie.rossjohn@monash.edu.au.
Travis Beddoethe Department of Animal, Plant and Soil Science and Centre for AgriBioscience, La Trobe University, Bundoora, Victoria 3086, Australia t.beddoe@latrobe.edu.au.
Australian Regenerative Medicine Institute · AUMonash University · AUUniversity of Adelaide · AUUniversity of Queensland · AUAgriBio · AUARC Centre of Excellence in Advanced Molecular Imaging · AUTechnion – Israel Institute of Technology · IL

Funding

Structural Basis of Immune Recognition of Glycosylated AntigensU54GM062116 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI PAULSON, JAMES C · 2001 to 2010
$80.3M
Overall Priority Score P41GM103694 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D · 2013 to 2018
$6.9M
Protein-Glycan Interaction Resource of the CFGR24GM098791 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D, PAULSON, JAMES C · 2011 to 2013
$2.6M
NIGMS NIH HHS P41 GM103694NIGMS NIH HHS R24 GM098791NIGMS NIH HHS U54 GM062116
6 · The paper itself

Abstract

Pertussis-like toxins are secreted by several bacterial pathogens during infection. They belong to the AB

Indexed as

AnimalsBacterial ToxinsCell ProliferationChlorocebus aethiopsDose-Response Relationship, DrugEpithelial CellsEscherichia coliHEK293 CellsHeterotrimeric GTP-Binding ProteinsHumansModels, MolecularPertussis ToxinStructure-Activity RelationshipVero CellsBacterial ToxinsHeterotrimeric GTP-Binding ProteinsPertussis ToxinADP-ribosylationbacterial toxinBordetella pertussischolera toxinEscherichia coli (E. coli)host-pathogen interactiontoxin

Identifiers

PMID28663369
PMCPMC5592689
OpenAlexW2724230620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.