ArticleThe European respiratory journal2017
The asbestos fibre burden in human lungs: new insights into the chrysotile debate.
Article in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 76 citations in OpenAlex.
- Evaluating the QEAS-7 questionnaire as a predictor of asbestos burden in lung tissue among lung cancer patients: insights from the AMCANES study.Frontiers in toxicology · 2026Article
- [Asbestos: detection and characterization in tissue].Pathologie (Heidelberg, Germany) · 2024Review
- Global, regional, and national burden of non-communicable diseases attributable to occupational asbestos exposure 1990-2019 and prediction to 2035: worsening or improving?BMC public health · 2024Article
- The incidence of malignancies in asbestosis with chrysotile exposure: a large Chinese prospective cohort study.Frontiers in oncology · 2023Article
- Elemental Mapping of Human Malignant Mesothelioma Tissue Samples Using High-Speed LA-ICP-TOFMS Imaging.Analytical chemistry · 2022Article
- Ongoing downplaying of the carcinogenicity of chrysotile asbestos by vested interests.Journal of occupational medicine and toxicology (London, England) · 2021Article
- Inorganic Fiber Lung Burden in Subjects with Occupational and/or Anthropogenic Environmental Asbestos Exposure in Broni (Pavia, Northern Italy): An SEM-EDS Study on Autoptic Samples.International journal of environmental research and public health · 2021Article
- An Emerging Model for Cancer Development from a Tumor Microenvironment Perspective in Mice and Humans.Advances in experimental medicine and biology · 2020Review
- Prevention of Asbestos Exposure in Latin America within a Global Public Health Perspective.Annals of global health · 2019Review
- Asbestos Bodies Burden in the Autopsy Lung Tissue from General Thai Population.The open respiratory medicine journal · 2019Article
- [The German Mesothelioma Register : Current pathological diagnostics and services].Der Pathologe · 2018Review
- [Mesothelioma].Der Pathologe · 2017Article
- Amphibole asbestos as an environmental trigger for systemic autoimmune diseases.Autoimmunity reviewsReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The traceability of asbestos fibres in human lungs is a matter of discussion especially for chrysotile. This issue is of high significance for differential diagnosis, risk assessment and occupational compensation. At present no intra-individual longitudinal information is available. This study addresses the question whether the asbestos fibre burden in human lungs decreases with time after exposure cessation.The database of the German Mesothelioma Register was screened for patients with asbestos body counts of at least 500 fibres per gram of wet lung, which had been analysed twice from different tissue excisions at minimum intervals of 4 years.Twelve datasets with individual longitudinal information were discovered with a median interval of about 8 years (range 4-21 years). Both examinations were performed after exposure cessation (median: surgery, 9.5 years; autopsy, 22 years). Pulmonary asbestos fibre burden was stable between both examinations (median 1623/4269 asbestos bodies per gram wet lung). Electron microscopy demonstrated a preponderance of chrysotile (median 80%).This study is the first to present longitudinal intra-individual data about the asbestos fibre burden in living human lungs. The high biopersistence of amphiboles, but also of chrysotile, offers mechanistic explanations for fibre toxicity, especially the long latency period of asbestos-related diseases.
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