ArticleOccupational and environmental medicine2017
Application of linear mixed-effects model with LASSO to identify metal components associated with cardiac autonomic responses among welders: a repeated measures study.
Article in Occupational and environmental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Investigation of relationship between occupational exposure to aerosol and sleep problems: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Longitudinal changes in cardiovascular disease-related proteins in welders.International archives of occupational and environmental health · 2024Article
- Mixture effects of trace element levels on cardiovascular diseases and type 2 diabetes risk in adults using G-computation analysis.Scientific reports · 2024Article
- Post hoc subgroup analysis and identification-learning more from existing data.European journal of clinical nutrition · 2023Article
- Effect of welding fumes on the cardiovascular system: a six-year longitudinal study.Scandinavian journal of work, environment & health · 2021Article
- Long-term exposure to ambient fine particulate matter and fasting blood glucose level in a Chinese elderly cohort.The Science of the total environment · 2020Article
- Continuous monitoring of cerebrovascular reactivity through pulse transit time and intracranial pressure.Physiological measurement · 2019Article
- Association between Dietary Intake and Coronary Artery Calcification in Non-Dialysis Chronic Kidney Disease: The PROGREDIR Study.Nutrients · 2018Article
- Preoperative profile of inflammatory factors in aqueous humor correlates with postoperative inflammatory response in patients with congenital cataract.Molecular vision · 2018Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnvironmental and occupational exposure to metals is ubiquitous worldwide, and understanding the hazardous metal components in this complex mixture is essential for environmental and occupational regulations.
objectiveTo identify hazardous components from metal mixtures that are associated with alterations in cardiac autonomic responses.
methodsUrinary concentrations of 16 types of metals were examined and 'acceleration capacity' (AC) and 'deceleration capacity' (DC), indicators of cardiac autonomic effects, were quantified from ECG recordings among 54 welders. We fitted linear mixed-effects models with least absolute shrinkage and selection operator (LASSO) to identify metal components that are associated with AC and DC. The Bayesian Information Criterion was used as the criterion for model selection procedures.
resultsMercury and chromium were selected for DC analysis, whereas mercury, chromium and manganese were selected for AC analysis through the LASSO approach. When we fitted the linear mixed-effects models with 'selected' metal components only, the effect of mercury remained significant. Every 1 µg/L increase in urinary mercury was associated with -0.58 ms (-1.03, -0.13) changes in DC and 0.67 ms (0.25, 1.10) changes in AC.
conclusionOur study suggests that exposure to several metals is associated with impaired cardiac autonomic functions. Our findings should be replicated in future studies with larger sample sizes.
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