Evidence map›Paper›PMID 28663255›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2017

Subcutaneous Adipocyte Lipolysis Contributes to Circulating Lipid Levels.

Mikael Rydén, Peter Arner

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06377358 (Lipolysis of Visceral Reserve Fat Using Tecar Therapy), which is not on this map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06377358 nacompletednot on this mapstarted 2022, after this paper: background citation

Lipolysis of Visceral Reserve Fat Using Tecar Therapy: Anthropometric, Biochemical and NMR Imaging Study.

TypeinterventionalSponsorCAPENERGY MEDICAL, SLRan2022 to 2023Enrolled20ConditionsObesity, Visceral, Obesity, EndocrineArmsTecar Therapy
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mikael RydénFrom the Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden. peter.arner@ki.se mikael.ryden@ki.se.
Peter ArnerFrom the Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden. peter.arner@ki.se mikael.ryden@ki.se.
Karolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFatty acids released via fat cell lipolysis can affect circulating lipid levels. However, the contribution of different lipolysis measures in adipose tissue is unknown and was presently examined in isolated subcutaneous adipocytes. APPROACH AND

resultsOne thousand and sixty-six men and women were examined for lipolysis regulation in subcutaneous abdominal fat cells. Results were compared with fasting plasma levels of total cholesterol, high-density lipoprotein (HDL) cholesterol (HDL-C) and triglycerides. Spontaneous (basal) lipolysis and the effects of the major hormones stimulating (catecholamines and natriuretic peptides) and inhibiting lipolysis (insulin) were examined. Several statistically significant (

conclusionsSubcutaneous fat cell lipolysis is an important independent contributor to interindividual variations in plasma lipids. High spontaneous lipolysis activity and resistance to the antilipolytic effect of insulin associate with elevated triglyceride and low HDL-C concentrations. Thus, although several other factors also play a role, subcutaneous adipose tissue may have a causal influence on dyslipidemia.

Indexed as

LipolysisAdipocytes, WhiteAdolescentAdultAgedAntihypertensive AgentsBiomarkersCholesterol, HDLFemaleHumansHypoglycemic AgentsHypolipidemic AgentsLipidsMaleMiddle AgedSubcutaneous Fat, AbdominalAntihypertensive AgentsBiomarkersCholesterol, HDLHypoglycemic AgentsHypolipidemic AgentsLipidsTriglyceridescatecholaminescholesterolinsulinnatriuretic peptidestriglycerides

Identifiers

PMID28663255
PMCPMC5567402
OpenAlexW2728309825

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.