Evidence map›Paper›PMID 28663251›Full record

SynthesisJournal of the American Heart Association2017

Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta-Analysis of Prospective Studies.

Yoriko Heianza, Wenjie Ma, JoAnn E Manson, Kathryn M Rexrode, Lu Qi

2 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 301 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
301citing papers in PubMed, 10 pooled it
21.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005152 active not recruitingnot on this map

Nurses' Health Study (Cardiovascular Component)

TypeobservationalSponsorBrigham and Women's HospitalRan1980 to 2029Enrolled121,700ConditionsCardiovascular Diseases, Diabetes Mellitus, Coronary Disease, Heart Diseases
NCT05071196 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Impact of Facilitated Vegan Diet on Cardiometabolic Endpoints and Trimethylamine N-oxide

TypeinterventionalSponsorDavid Grant U.S. Air Force Medical CenterRan2022 to 2022Enrolled70ConditionsCardiometabolic Risk FactorsArmsFacilitated Vegan Diet, Omnivorous Diet
3 · Its place in the literature

Who cites it

301 citing papers in PubMed, 10 syntheses or guidelines pooled it, 527 citations in OpenAlex.

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  11. Plasma Trimethylamine-Journal of the American Heart Association · 2023
    Trial
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  16. Review
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241 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yoriko HeianzaDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.
Wenjie MaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
JoAnn E MansonDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Kathryn M RexrodeDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Lu QiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA lqi1@tulane.edu.
Harvard University · USTulane University · USBrigham and Women's Hospital · US

Funding

RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Risk Factors for Ischemic Stroke in WomenR01HL088521 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REXRODE, KATHRYN M · 2008 to 2025
$9.9M
NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL088521
6 · The paper itself

Abstract

backgroundGut microbial metabolites have been implicated as novel risk factors for cardiovascular events and premature death. The strength and consistency of associations between blood concentrations of the gut microbial metabolites, trimethylamine-N-oxide (TMAO) and its precursors, with major adverse cardiovascular events (MACE) or death have not been comprehensively assessed. We quantified associations of blood concentrations of TMAO and its precursors with risks of MACE and mortality. METHODS AND

resultsPubMed and Embase databases were searched up, and a total of 19 prospective studies from 16 publications (n=19 256, including 3315 incident cases) with quantitative estimates of the associations of TMAO with the development of MACE or death were included in our main analysis. Multivariate-adjusted relative risks (RRs) were used when these were available. Elevated concentrations of TMAO were associated with a pooled RR of 1.62 (95% CI, 1.45, 1.80;

conclusionsElevated concentrations of TMAO and its precursors were associated with increased risks of MACE and all-cause mortality independently of traditional risk factors.

Indexed as

AgedBiomarkersCardiovascular DiseasesCause of DeathGastrointestinal MicrobiomeHumansMethylaminesMiddle AgedProspective StudiesRisk FactorsBiomarkersMethylaminestrimethyloxaminemajor adverse cardiovascular eventsmeta‐analysisrisktrimethylamine N‐oxide

Identifiers

PMID28663251
PMCPMC5586261
OpenAlexW2729775538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.