Evidence map›Paper›PMID 28663236›Full record

ArticleBiology open2017

Manipulation and quantification of microtubule lattice integrity.

Taylor A Reid, Courtney Coombes, Melissa K Gardner

Open access · goldAbstract read
In one paragraph

Article in Biology open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. SSNA1 mechanically reinforces the damaged microtubule lattice.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Mechanical fatigue in microtubules.Scientific reports · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Taylor A ReidDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Courtney CoombesDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Melissa K GardnerDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA klei0091@umn.edu.ORCID http://orcid.org/0000-0001-5906-7363
University of Minnesota · US

Funding

Gardner Lab MIRA Proposal: Microtubules and MitosisR35GM126974 · NIGMS · UNIVERSITY OF MINNESOTA · PI Melissa Gardner · 2018 to 2026
$3.4M
Quantitative Analysis and Modeling of Microtubule Structure and RegulationR01GM103833 · NIGMS · UNIVERSITY OF MINNESOTA · PI GARDNER, MELISSA · 2013 to 2017
$1.4M
NIGMS NIH HHS R01 GM103833NIGMS NIH HHS R35 GM126974
6 · The paper itself

Abstract

Microtubules are structural polymers that participate in a wide range of cellular functions. The addition and loss of tubulin subunits allows the microtubule to grow and shorten, as well as to develop and repair defects and gaps in its cylindrical lattice. These lattice defects act to modulate the interactions of microtubules with molecular motors and other microtubule-associated proteins. Therefore, tools to control and measure microtubule lattice structure will be invaluable for developing a quantitative understanding of how the structural state of the microtubule lattice may regulate its interactions with other proteins. In this work, we manipulated the lattice integrity of

Indexed as

GMPCPPLatticeMicrotubuleStructureTaxol

Identifiers

PMID28663236
PMCPMC5576077
OpenAlexW2731545473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.