Evidence map›Paper›PMID 28663230›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Tissue-Specific MicroRNA Expression Patterns in Four Types of Kidney Disease.

Maria Angeles Baker, Seth J Davis, Pengyuan Liu, Xiaoqing Pan, Anna Marie Williams, Kenneth A Iczkowski, Sean T Gallagher, Kaylee Bishop, Kevin R Regner, Yong Liu and 1 more

Open access · bronzeAbstract readComparative StudyValidation Study
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 115 citations in OpenAlex.

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  17. TNF inhibits AQP2 expression via a miR137-dependent pathway.American journal of physiology. Renal physiology · 2024
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Maria Angeles BakerCenter of Systems Molecular Medicine, Department of Physiology.
Seth J DavisCenter of Systems Molecular Medicine, Department of Physiology.
Pengyuan LiuCenter of Systems Molecular Medicine, Department of Physiology.
Xiaoqing PanCenter of Systems Molecular Medicine, Department of Physiology.
Anna Marie WilliamsCenter of Systems Molecular Medicine, Department of Physiology.
Kenneth A IczkowskiDepartment of Pathology, and.
Sean T GallagherCenter of Systems Molecular Medicine, Department of Physiology.
Kaylee BishopCenter of Systems Molecular Medicine, Department of Physiology.
Kevin R RegnerDivision of Nephrology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Yong LiuCenter of Systems Molecular Medicine, Department of Physiology.
Mingyu LiangCenter of Systems Molecular Medicine, Department of Physiology, mliang@mcw.edu.
Medical College of Wisconsin · US

Funding

Stem Cell CoreP01GM066730 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI DASH, RANJAN K · 2003 to 2019
$23.6M
INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Regulatory RNA in Hypertension and Renal InjuryR01HL121233 · NHLBI · UNIVERSITY OF ARIZONA · PI MINGYU LIANG · 2014 to 2026
$3.8M
MicroRNA-29b and Endothelial FunctionR01HL125409 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI LIANG, MINGYU, WIDLANSKY, MICHAEL E · 2015 to 2018
$2.0M
NIDDK Research Education ProgramR25DK098104 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI DWINELL, MICHAEL B, REGNER, KEVIN R. · 2013 to 2017
$273k
NHLBI NIH HHS R01 HL121233NHLBI NIH HHS R01 HL125409NHLBI NIH HHS T32 HL007852NIDDK NIH HHS R25 DK098104NIGMS NIH HHS P01 GM066730
6 · The paper itself

Abstract

MicroRNAs contribute to the development of kidney disease. Previous analyses of microRNA expression in human kidneys, however, were limited by tissue heterogeneity or the inclusion of only one pathologic type. In this study, we used laser-capture microdissection to obtain glomeruli and proximal tubules from 98 human needle kidney biopsy specimens for microRNA expression analysis using deep sequencing. We analyzed specimens from patients with diabetic nephropathy (DN), FSGS, IgA nephropathy (IgAN), membranoproliferative GN (MPGN) (

Indexed as

BiomarkersCase-Control StudiesHumansKidney DiseasesKidney Function TestsKidney GlomerulusKidney Tubules, ProximalMicroRNAsRNA, MessengerBiomarkersMicroRNAsRNA, Messengerbiopsychronic kidney diseaseglomeruluskidneymicroRNAproximal tubule

Identifiers

PMID28663230
PMCPMC5619963
OpenAlexW2729069035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.