Evidence map›Paper›PMID 28663095›Full record

SynthesisNeuroscience2017

Meta-analysis of stem cell transplantation for reflex hypersensitivity after spinal cord injury.

Xuemei Chen, Bohan Xue, Yuping Li, Chunhua Song, Peijun Jia, Xiuhua Ren, Weidong Zang, Jian Wang

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 4 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Is cell transplantation a reliable therapeutic strategy for spinal cord injury in clinical practice? A systematic review and meta-analysis from 22 clinical controlled trials.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019
    Pooled it
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Xuemei ChenDepartment of Human Anatomy, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan, PR China. Electronic address: chenxm@zzu.edu.cn.
Bohan XueDepartment of Human Anatomy, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan, PR China.
Yuping LiDepartment of Human Anatomy, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan, PR China.
Chunhua SongDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, PR China.
Peijun JiaDepartment of Human Anatomy, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan, PR China.
Xiuhua RenDepartment of Human Anatomy, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan, PR China.
Weidong ZangDepartment of Human Anatomy, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan, PR China. Electronic address: zwd@zzu.edu.cn.
Jian WangDepartment of Human Anatomy, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan, PR China; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Zhengzhou University · CN

Funding

Neuroprotective effect of flavanol (-) epicatechin after intracerebral hemorrhageR01AT007317 · NCCIH · JOHNS HOPKINS UNIVERSITY · PI WANG, JIAN · 2012 to 2016
$2.0M
PGE2 EP1 and EP3 receptors as therapeutic targets in intracerebral hemorrhageR01NS078026 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WANG, JIAN · 2012 to 2016
$1.8M
NCCIH NIH HHS R01 AT007317NINDS NIH HHS R01 NS078026
6 · The paper itself

Abstract

Stem cells have been used in novel therapeutic strategies for spinal cord injury (SCI), but the effect of stem cell transplantation on neuropathic pain after SCI is unclear. The current meta-analysis evaluates the effects of stem cell transplantation on neuropathic pain after SCI. We first conducted online searches of PubMed, Web of Science, China Academic Journals Full-text Database, and Wanfang Data for randomized controlled trials that compared stem cell transplantation and vehicle treatments in rodent models of neuropathic pain after SCI. Quality assessment was performed using Cochrane Reviewer's Handbook 5.1.0, and meta-analysis was conducted with RevMan 5.3. Then, we developed a rat model of SCI and transplanted bone marrow mesenchymal stem cells to verify meta-analysis results. Twelve randomized, controlled trials (n=354 total animals) were included in our meta-analysis and divided by subgroups, including species, timing of behavioral measurements, and transplantation time after SCI. Subgroup analysis of these 12 studies indicated that stem cell-treated animals had a higher mechanical reflex threshold than vehicle groups, with a significant difference in both rats and mice. The thermal withdrawal latency showed the same results in mouse subgroups, but not in rat subgroups. In addition, mesenchymal stem cell transplantation was an effective treatment for mechanical, but not thermal reflex hypersensitivity relief in rats. Transplantation showed a positive effect when carried out at 3 or 7days post-SCI. Stem cell transplantation alleviates mechanical reflex hypersensitivity in rats and mice and thermal reflex hypersensitivity in mice after SCI.

Indexed as

AnimalsHyperalgesiaMiceNeuralgiaRatsRats, Sprague-DawleySpinal Cord InjuriesStem Cell Transplantationmeta-analysisneuropathic painspinal cord injurystem cells

Identifiers

PMID28663095
PMCPMC5636655
OpenAlexW2723964534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.