Evidence map›Paper›PMID 28662798›Full record

ArticleJournal of the American College of Cardiology2017

Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels.

Kafa Walweel, Nieves Gomez-Hurtado, Ye Wint Oo, Nicole A Beard, Cris Dos Remedios, Christopher N Johnson, Walter J Chazin, Dirk F van Helden, Björn C Knollmann, Derek R Laver

Open access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kafa Walweel
Nieves Gomez-Hurtado
Ye Wint Oo
Nicole A Beard
Cris Dos Remedios
Christopher N Johnson
Walter J Chazin
Dirk F van Helden
Björn C Knollmann
Derek R Laver

Funding

Structural Biology of Multi-Domain Proteins and Multi-Protein Machinery in DNA Replication and RepairR35GM118089 · NIGMS · VANDERBILT UNIVERSITY · PI WALTER J. CHAZIN · 2016 to 2026
$4.9M
Toward a Mechanism-Based Approach to Treating Atrial FibrillationR01HL124935 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2015 to 2019
$2.8M
Flecainide for Catecholaminergic Polymorphic Ventricular TachycardiaR01HL108173 · NHLBI · VANDERBILT UNIVERSITY · PI KANNANKERIL, PRINCE JOSEPH, KNOLLMANN, BJORN C · 2011 to 2014
$2.2M
Pannexin channels in cardiac arrhythmiasR01HL128044 · NHLBI · VANDERBILT UNIVERSITY · PI KNOLLMANN, BJORN C, ZHOU, LUFANG · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL108173NHLBI NIH HHS R01 HL124935NHLBI NIH HHS R01 HL128044NIGMS NIH HHS R35 GM118089
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Heart VentriclesTachycardia, VentricularCalmodulinHumansIn Vitro TechniquesMutationPhosphorylationPolymorphic Catecholaminergic Ventricular TachycardiaRyanodine Receptor Calcium Release ChannelCalmodulinRyanodine Receptor Calcium Release Channel

Identifiers

PMID28662798
PMCPMC7162611
OpenAlexW2685057422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.