ArticleBMC genomics2017
Integrated transcriptomics and metabolomics analysis to characterize cold stress responses in Nicotiana tabacum.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69 citing papers in PubMed, 151 citations in OpenAlex.
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- Dynamic transcriptomic and metabolomic adaptation mechanisms of Trifolium ambiguum under different durations of cold stress.Scientific reports · 2025Article
- The Transcriptional and Translational Landscape of Plant Adaptation to Low Temperatures.International journal of molecular sciences · 2025Article
- Network-based identification of hub transcription factors associated with benzylisoquinoline alkaloid biosynthesis inBiochemistry and biophysics reports · 2025Article
- Unraveling the response of secondary metabolites to cold tolerance in oil palm by integration of physiology and metabolomic analyses.BMC plant biology · 2025Article
- Integrating Transcriptomics and Metabolomics to Comprehensively Analyze Phytohormone Regulatory Mechanisms inInternational journal of molecular sciences · 2025Article
- Cold stress adaptation inFrontiers in plant science · 2025Article
- Multiomic analyses reveal transcription factors involved in the fatty acid biosynthesis pathway under cold stress in upland cotton (Frontiers in plant science · 2025Article
- Compared analysis of physiology and transcriptomics reveals superior cold tolerance in CV-1 compared to K326.Frontiers in plant science · 2025Article
- Integrated Transcriptomic, Proteomic, and Metabolomic Analyses Revealed Molecular Mechanism for Salt Resistance in Soybean (International journal of molecular sciences · 2024Article
- Muti-omics revealed the mechanisms of MT-conferred tolerance of Elymus nutans Griseb. to low temperature at XiZang.BMC plant biology · 2024Article
- Article
- Integrated miRNA and mRNA Transcriptome Analysis Reveals Regulatory Mechanisms in the Response of WinterInternational journal of molecular sciences · 2024Article
- Jasmonate enhances cold acclimation in jojoba by promoting flavonol synthesis.Horticulture research · 2024Article
- Integrated transcriptomic and metabolomic analysis provides insights into cold tolerance in lettuce (Lactuca sativa L.).BMC plant biology · 2024Article
- Integrated transcriptomics and metabolomics provides insights into theFrontiers in plant science · 2024Article
- Responses of transcriptome and metabolome in peanut leaves to dibutyl phthalate during whole growth period.Frontiers in plant science · 2024Article
- Chilling stress response in tobacco seedlings: insights from transcriptome, proteome, and phosphoproteome analyses.Frontiers in plant science · 2024Article
- Full-length transcriptome sequencing provides insights into alternative splicing under cold stress in peanut.Frontiers in plant science · 2024Article
- Orthogroup and phylotranscriptomic analyses identify transcription factors involved in the plant cold response: A case study of Arabidopsis BBX29.Plant communications · 2023Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCB-1 and K326 are closely related tobacco cultivars; however, their cold tolerance capacities are different. K326 is much more cold tolerant than CB-1.
resultsWe studied the transcriptomes and metabolomes of CB-1 and K326 leaf samples treated with cold stress. Totally, we have identified 14,590 differentially expressed genes (DEGs) in CB-1 and 14,605 DEGs in K326; there was also 200 differentially expressed metabolites in CB-1 and 194 in K326. Moreover, there were many overlapping genes (around 50%) that were cold-responsive in both plant cultivars, although there were also many differences in the cold responsive genes between the two cultivars. Importantly, for most of the overlapping cold responsive genes, the extent of the changes in expression were typically much more pronounced in K326 than in CB-1, which may help explain the superior cold tolerance of K326. Similar results were found in the metabolome analysis, particularly with the analysis of primary metabolites, including amino acids, organic acids, and sugars. The large number of specific responsive genes and metabolites highlight the complex regulatory mechanisms associated with cold stress in tobacco. In addition, our work implies that the energy metabolism and hormones may function distinctly between CB-1 and K326.
conclusionsDifferences in gene expression and metabolite levels following cold stress treatment seem likely to have contributed to the observed difference in the cold tolerance phenotype of these two tobacco cultivars.
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