ArticleThe American journal of drug and alcohol abuse2018
Interaction between the ADH1B*3 allele and drinking motives on alcohol use among Black college students.
Article in The American journal of drug and alcohol abuse, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 20 citations in OpenAlex.
- Analysis of alcohol-metabolizing enzymes genetic variants and RAR/RXR expression in patients diagnosed with fetal alcohol syndrome: a case-control study.BMC genomics · 2024Article
- Gene-alcohol interactions in birth defects.Current topics in developmental biology · 2023Article
- Racial/ethnic discrimination, ADH1B*3, and coping-motivated drinking among Black college students.The American journal on addictions · 2022Article
- A systems omics-based approach to decode substance use disorders and neuroadaptations.Neuroscience and biobehavioral reviews · 2021Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBlack young adults have lower rates of alcohol use than other racial groups. Genetic factors may protect against drinking. Specifically, the ADH1B*3 allele is present almost exclusively in Black populations and has been protective against alcohol use and alcohol use disorder. The protective effects of the ADH1B*3 allele, however, may differ as a function of alcohol-promoting cognitions.
objectivesThe current study examined whether ADH1B*3 moderated relations of drinking motives with alcohol consumption among Black college drinkers.
methodsParticipants were 241 undergraduate students of self-identified Black race (mean age = 20 years; 66% female) who reported consuming alcohol at least once in the past 30 days.
resultsADH1B*3 was not significantly associated with drinking motives or drinking behaviors. However, significant, albeit small, interaction effects of ADH1B*3 with drinking motives on drinking behavior were found; the presence of an ADH1B*3 allele protected against greater drinking quantity among students with high social motives (incidence rate ratio [IRR] = 0.95, 95% CI [0.92, 0.99]) and against frequent drinking among students with low coping motives (IRR = 1.06, 95% CI [1.01, 1.11]).
conclusionThese findings represent a novel demonstration of genetic modulation of alcohol-related cognitions within Black college drinkers, although replication is needed. Results represent an initial step toward better characterizing individual differences in associations of drinking motives with drinking behavior, with potential implications for interventions aimed at motivational processes in alcohol use.
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