ArticlePloS one2017
Effects of iron supplementation on growth, gut microbiota, metabolomics and cognitive development of rat pups.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- The Gut-Iron-Immune Axis in Severe Anaemia and Bacteraemia.Nutrients · 2026Review
- Metabolomic Profiling of Serum Reveals Energy Metabolism Differences in Nellore Bulls with Divergent Growth Rates during Feedlot Finishing.ACS omega · 2025Article
- Infantile Anemia and Iron Treatments Affect the Gut Microbiome of Young Rhesus Monkeys.Microorganisms · 2025Article
- Dietary iron intake has long-term effects on the fecal metabolome and microbiome.Metallomics : integrated biometal science · 2024Article
- Prognostic Performance of Hematological and Serum Iron and Metabolite Indices for Detection of Early Iron Deficiency Induced Metabolic Brain Dysfunction in Infant Rhesus Monkeys.The Journal of nutrition · 2024Article
- Toxic and essential metals: metabolic interactions with the gut microbiota and health implications.Frontiers in nutrition · 2024Review
- Metallobiology of Lactobacillaceae in the gut microbiome.Journal of inorganic biochemistry · 2023Review
- Benefits and Risks of Early Life Iron Supplementation.Nutrients · 2022Review
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- Effects of iron deficiency and iron supplementation at the host-microbiota interface: Could a piglet model unravel complexities of the underlying mechanisms?Frontiers in nutrition · 2022Review
- Iron Reshapes the Gut Microbiome and Host Metabolism.Journal of lipid and atherosclerosis · 2021Review
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- Article
- Preterm neonatal immunology at the intestinal interface.Cellular and molecular life sciences : CMLS · 2020Review
- A decrease in iron availability to human gut microbiome reduces the growth of potentially pathogenic gut bacteria; an in vitro colonic fermentation study.The Journal of nutritional biochemistry · 2019Article
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- Excess iron intake as a factor in growth, infections, and development of infants and young children.The American journal of clinical nutrition · 2017Review
- Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIron deficiency is common during infancy and therefore iron supplementation is recommended. Recent reports suggest that iron supplementation in already iron replete infants may adversely affect growth, cognitive development, and morbidity.
methodsNormal and growth restricted rat pups were given iron daily (30 or 150 μg/d) from birth to postnatal day (PD) 20, and followed to PD56. At PD20, hematology, tissue iron, and the hepatic metabolome were measured. The plasma metabolome and colonic microbial ecology were assessed at PD20 and PD56. T-maze (PD35) and passive avoidance (PD40) tests were used to evaluate cognitive development.
resultsIron supplementation increased iron status in a dose-dependent manner in both groups, but no significant effect of iron on growth was observed. Passive avoidance was significantly lower only in normal rats given high iron compared with controls. In plasma and liver of normal and growth-restricted rats, excess iron increased 3-hydroxybutyrate and decreased several amino acids, urea and myo-inositol. While a profound difference in gut microbiota of normal and growth-restricted rats was observed, with iron supplementation differences in the abundance of strict anaerobes were observed.
conclusionExcess iron adversely affects cognitive development, which may be a consequence of altered metabolism and/or shifts in gut microbiota.
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Registered trials
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