ArticlePloS one2017
Longitudinal changes in macular retinal layer thickness in pediatric populations: Myopic vs non-myopic eyes.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Normative data for optical coherence tomography in children: a systematic review.Eye (London, England) · 2021Pooled it
- Changes in choroidal and retinal thickness 6 months before and during 18 months of orthokeratology lens treatment in myopic children.Acta ophthalmologica · 2026Article
- Behavioral and Structural Correlates of Axial Length in School-Aged Children: Baseline Findings from the Seoul Myopia Cohort Study.Life (Basel, Switzerland) · 2026Article
- Comparison of Two Spectral-Domain Optical Coherence Tomographs for Macular Thickness in Romanian Children Reveals Device-Dependent Normative Data and Significant Gender Differences.Diagnostics (Basel, Switzerland) · 2026Article
- Subclinical Microvascular Deficits as a Promising Biomarker for Functional Impairment in Non-Pathological High Myopia: A Cross-Sectional Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Article
- Optic Nerve Head Morphology and Macula Ganglion Cell Inner Plexiform Layer Thickness in Axially Anisometropic Rhesus Monkeys.Investigative ophthalmology & visual science · 2024Article
- The Association of Myopia Progression with Changes in Retinal Thickness among Primary School Students with Myopia.Journal of ophthalmology · 2024Article
- Compartmental analysis of retinal vascular parameters and thickness in myopic eyes using SS-OCTA.Frontiers in medicine · 2024Article
- A variation of foveal morphology in a group of children with hypermetropia.International ophthalmology · 2023Article
- The age-related pattern of inner retinal thickening is affected by myopia development and progression.Scientific reports · 2022Article
- Development of the retina and its relation with myopic shift varies from childhood to adolescence.The British journal of ophthalmology · 2022Article
- Choroidal Thickening During Young Adulthood and Baseline Choroidal Thickness Predicts Refractive Error Change.Investigative ophthalmology & visual science · 2022Article
- Short-Term Effects of Atropine 0.01% on the Structure and Vasculature of the Choroid and Retina in Myopic Chinese Children.Ophthalmology and therapy · 2022Article
- OCT Retinal and Choroidal Layer Instance Segmentation Using Mask R-CNN.Sensors (Basel, Switzerland) · 2022Article
- Longitudinal Changes in Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell Inner Plexiform Layer in Progressive Myopia and Glaucoma Among Adolescents.Frontiers in medicine · 2022Article
- Retinal thickness in healthy Australian Aboriginal and Torres Strait Islander children.PloS one · 2022Article
- Normative Data of Macular Thickness Using Spectral Domain Optical Coherence Tomography for Healthy Jordanian Children.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Macular Thickness Profile and Its Association With Best-Corrected Visual Acuity in Healthy Young Adults.Translational vision science & technology · 2021Article
- Comparison of Retinal Layer Thicknesses of Highly Myopic Eyes and Normal Eyes.Korean journal of ophthalmology : KJO · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge of the normal in vivo thickness of the retina, and its individual layers in pediatric populations is important for diagnosing and monitoring retinal disorders, and for understanding the eye's normal development and the impact of eye growth and refractive error such as myopia (short-sightedness) upon retinal morphology. In this prospective, observational longitudinal study, total retinal thickness (and individual retinal layer thickness) and the changes in retinal morphology occurring over an 18-month period were examined in 101 children with a range of refractive errors. In childhood, the presence of myopia was associated with subtle but statistically significant (p<0.05) changes in the topographical thickness distribution of macular retinal thickness (and retinal layer thickness), characterised by a thinning of the parafoveal retina (and parafoveal or perifoveal thinning in most outer and inner retinal layers). The parafoveal retina was on average 6 μm thinner in myopic children. However, over 18 months, longitudinal changes in retinal thickness and individual layers were of small magnitude (average changes of less than 2 μm over 18 months), indicative of a high degree of stability in retinal morphology in healthy adolescent eyes, despite significant eye growth over this same period of time. This provides the first detailed longitudinal assessment of macula retinal layer morphology in adolescence, and delivers new normative data on expected changes in retinal structure over time and associated with myopia during this period of childhood development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.