ArticlePloS one2017
Diminished physical function in older HIV-infected adults in the Southeastern U.S. despite successful antiretroviral therapy.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Effects of High-Intensity Functional Exercise on Cardiorespiratory Fitness and Physical Function in Older Adults With HIV: A Telerehabilitation Randomized Trial.Open forum infectious diseases · 2026Article
- HIV-associated lung disease.Nature reviews. Disease primers · 2023Review
- Frailty in older people living with HIV: current status and clinical management.BMC geriatrics · 2022Review
- The Role of Depressive Symptoms and Physical Activity Levels in Mediating the Association Between HIV Status and Neurocognitive Functions Among Individuals Aged at Least 50 Years in China: Cross-sectional Study.JMIR public health and surveillance · 2022Article
- Insights Into Persistent HIV-1 Infection and Functional Cure: Novel Capabilities and Strategies.Frontiers in microbiology · 2022Review
- A Unique Gut Microbiome-Physical Function Axis Exists in Older People with HIV: An Exploratory Study.AIDS research and human retroviruses · 2021Article
- Social support moderates D-dimer and self-rated successful aging within people with HIV and older adults.Journal of behavioral medicine · 2020Article
- Article
- Depressive symptoms, physical symptoms, and health-related quality of life among older adults with HIV.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Dopaminergic impact of cART and anti-depressants on HIV neuropathogenesis in older adults.Brain research · 2019Review
- HIV infection is an independent risk factor for decreased 6-minute walk test distance.PloS one · 2019Article
- Low Levels of Physical Activity Among Older Persons Living with HIV/AIDS Are Associated with Poor Physical Function.AIDS research and human retroviruses · 2018Article
- Racial Differences in Change in Physical Functioning in Older Male Veterans with HIV.AIDS research and human retrovirusesArticle
- Adherence to Recommendations from Comprehensive Geriatric Assessment of Older Individuals with HIV.Journal of the International Association of Providers of AIDS CareArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundAs antiretroviral therapy efficacy improves, HIV is gradually being recognized more as a chronic disease within the aging HIV-infected population. While these individuals are surviving into old age, they may, however, be experiencing "accelerated aging" with greater declines in physical function than that observed among comparably matched individuals free of HIV. This decline is not well understood and it remains unclear if physical decline correlates with the degree of immunosuppression based on CD4 lymphocyte nadir.
methodsIn a cross-sectional study of accelerated aging in the older HIV-infected population on antiretroviral therapy (ART), physical performance evaluations were completed on a cohort of 107 HIV-infected subjects, age 50 years or older (with no HIV-1 RNA >200 copies/mL in the prior 12 months), and compared to reference ranges for age- and gender-matched HIV-uninfected persons. Physical performance testing consisted of four validated assessments: the 2.4-meter walk, 30-second chair stand, grip strength and 6-minute walk test.
resultsWhen compared to age- and gender-matched HIV-uninfected reference controls, older HIV-infected persons had diminished physical function. No correlation was found between physical function and degree of immunosuppression as determined by pre-ART CD4 nadir.
conclusionsDespite improved survival, HIV-infected adults on suppressive ART have diminished physical function compared to HIV-uninfected persons. The degree of HIV-associated immunosuppression does not correlate with the observed degree of physical function decline in older HIV-infected persons, suggesting the decline is mediated by other mechanisms.
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