Evidence map›Paper›PMID 28661908›Full record

ArticleNursing research

Associations Between Hormonal Biomarkers and Cognitive, Motor, and Language Developmental Status in Very Low Birth Weight Infants.

June Cho, Diane Holditch-Davis, Xiaogang Su, Vivien Phillips, Fred Biasini, Waldemar A Carlo

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

June ChoJune Cho, PhD, RN, was Assistant Professor, School of Nursing, University of Alabama at Birmingham, at the time this research was completed. She is now Associate Professor, School of Nursing, Duke University, Durham, North Carolina. Diane Holditch-Davis, PhD, RN, FAAN, is Professor Emerita, School of Nursing, Duke University, Durham, North Carolina. Xiaogang Su, PhD, is Associate Professor, Department of Mathematical Sciences, University of Texas at El Paso. Vivien Phillips, BSN, RN, is Research Nurse Coordinator, Division of Neonatology, Department of Pediatrics, School of Medicine, University of Alabama at Birmingham. Fred Biasini, PhD, is Associate Professor, Director of Alabama UCEDD and LEND, Director of Civitan/Sparks Clinics, and Director of UAB Early Head Start, Department of Psychology, University of Alabama at Birmingham. Waldemar A. Carlo, MD, is Professor, Director of Division of Neonatology, and Director of Newborn Nurseries, Department of Pediatrics, School of Medicine, University of Alabama at Birmingham.
Diane Holditch-Davis
Xiaogang Su
Vivien Phillips
Fred Biasini
Waldemar A Carlo
Duke University · US

Funding

Testosterone and Cortisol Levels in Infant Health and DevelopmentR01HD076871 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHO, JUNE I · 2014 to 2016
$959k
Perinatal Testosterone in Infant Health, Mother-Infant Interaction and DevelopmenR21HD066186 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHO, JUNE I · 2010 to 2011
$396k
NICHD NIH HHS R01 HD076871NICHD NIH HHS R21 HD066186
6 · The paper itself

Abstract

backgroundMale infants are more prone to health problems and developmental delays than female infants.

objectivesOn the basis of theories of gender differences in brain development and social relationships, we explored associations between testosterone and cortisol levels with infant cognitive, motor, and language development ("infant development") in very low birth weight (VLBW) infants, controlling for mother-infant interactions, characteristics of mothers and infants, and days of saliva collection after birth.

methodsA total of 62 mother-VLBW infant pairs were recruited from the newborn intensive care unit of a tertiary medical center in the Southeast United States. Data were collected through infant medical record review, biochemical measurement, observation of mother-infant interactions, and standard questionnaires. Infant development was assessed at 6 months corrected age (CA), and mother-infant interactions were observed at 3 and 6 months CA.

resultsGeneral linear regression with separate analyses for each infant gender showed that high testosterone levels were positively associated with language development of male infants after controlling for mother-infant interactions and other covariates, whereas high cortisol levels were negatively associated with motor development of female infants after controlling for mother-infant interactions.

conclusionsSteroid hormonal levels may well be more fundamental factors for assessing infant development than infant gender or mother-infant interactions at 6 months CA.

Indexed as

BiomarkersBrainChild DevelopmentHumansHydrocortisoneInfant, NewbornInfant, Very Low Birth WeightLanguageMaleMother-Child RelationsSalivaSex FactorsSoutheastern United StatesTestosteroneBiomarkersHydrocortisoneTestosterone

Identifiers

PMID28661908
PMCPMC5604880
OpenAlexW2730017887

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.