Evidence map›Paper›PMID 28661491›Full record

ArticleGenetics in medicine : official journal of the American College of Medical Genetics2017

Informed decision making and psychosocial outcomes in pregnant and nonpregnant women offered population fragile X carrier screening.

Sylvia A Metcalfe, Melissa Martyn, Alice Ames, Vicki Anderson, Alison D Archibald, Grad Dip Gen Couns, Rob Carter, Jonathan Cohen, Megan Cotter, M GenCouns and 27 more

Abstract read
PubMed Publisher
In one paragraph

Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
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  6. Review
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  14. Fragile X population carrier screening.Genetics in medicine : official journal of the American College of Medical Genetics · 2018
    Article
  15. Response to Metcalfe et al.Genetics in medicine : official journal of the American College of Medical Genetics · 2018
    Article
  16. Should we implement population screening for fragile X?Genetics in medicine : official journal of the American College of Medical Genetics · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors.

Sylvia A MetcalfeMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Melissa MartynMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Alice AmesMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Vicki AndersonMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Alison D ArchibaldMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Grad Dip Gen CounsMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Rob CarterFaculty of Health, Deakin Health Economics, Deakin University, Melbourne, Victoria, Australia.
Jonathan CohenFragile X Alliance Clinic and Centre for Developmental Disability Health Victoria, Monash University, Melbourne, Victoria, Australia.
Megan CotterMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
M GenCounsMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
William DangAustralian Clinical Labs (formerly Healthscope Pathology), Clayton, Victoria, Australia.
Martin B DelatyckiMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Susan DonathMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Samantha EdwardsSchool of Primary Aboriginal and Rural Health Care, University of Western Australia.
PGrad Dip EducSchool of Primary Aboriginal and Rural Health Care, University of Western Australia.
Grad Dip Gen CounsSchool of Primary Aboriginal and Rural Health Care, University of Western Australia.
Robin ForbesVictorian Clinical Genetics Services, Melbourne, Victoria, Australia.
Grad Dip Gen CounsVictorian Clinical Genetics Services, Melbourne, Victoria, Australia.
Mioara GavrilaAustralian Clinical Labs (formerly Healthscope Pathology), Clayton, Victoria, Australia.
M MedSciAustralian Clinical Labs (formerly Healthscope Pathology), Clayton, Victoria, Australia.
Jane HallidayMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Chriselle HickertonMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Melissa HillMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Grad Dip Gen CounsMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Lorilli JacobsSchool of Primary Aboriginal and Rural Health Care, University of Western Australia.
PGrad Dip UltrasoundSchool of Primary Aboriginal and Rural Health Care, University of Western Australia.
Vicki PetrouMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Grad Dip Gen CounsMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Loren PlunkettMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
M GenCounsMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Leslie SheffieldMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
F RacpMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Alison ThorntonMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Grad Dip Gen CounsMurdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Sandra YounieFaculty of Health, Deakin Health Economics, Deakin University, Melbourne, Victoria, Australia.
PGrad Dip Hlth EconFaculty of Health, Deakin Health Economics, Deakin University, Melbourne, Victoria, Australia.
Jon D EmerySchool of Primary Aboriginal and Rural Health Care, University of Western Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PurposePopulation-based carrier screening for fragile X syndrome (FXS) is still not universally endorsed by professional organizations due to concerns around genetic counseling for complex information and potential for psychosocial harms.MethodsWe determined uptake levels, decision making, and psychosocial impact in a prospective study of pregnant and nonpregnant Australian women offered FXS carrier screening in clinical settings. Women received pretest genetic counseling, and completed questionnaires when deciding and one month later.ResultsOf 1,156 women recruited, 83.1% returned the first questionnaire with 70.6% nonpregnant and 58.8% pregnant women choosing testing (χ

Indexed as

Decision MakingHeterozygoteAdolescentAdultAgedChoice BehaviorFemaleFragile X SyndromeGenetic TestingHumansMass ScreeningMiddle AgedPopulation SurveillancePregnancyPsychologySurveys and Questionnaires

Identifiers

PMID28661491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.