ArticleViruses2017
Effective Suckling C57BL/6, Kunming, and BALB/c Mouse Models with Remarkable Neurological Manifestation for Zika Virus Infection.
Article in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Single-cell RNA-seq provides insight into the underdeveloped immune system of germ-free mice.Zoological research · 2025Article
- Flaviviruses-Induced Neurological Sequelae.Pathogens (Basel, Switzerland) · 2024Review
- Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization.GeroScience · 2024Article
- Testicular damage without clinical manifestations in BALB/c mice experimentally infected with Zika virus.Animal reproduction · 2024Article
- EDIII-Fc induces protective immune responses against the Zika virus in mice and rhesus macaque.PLoS neglected tropical diseases · 2023Article
- Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models.Zoological research · 2023Review
- Mice 3D testicular organoid system as a novel tool to study Zika virus pathogenesis.Virologica Sinica · 2023Article
- The CD8+ and CD4+ T Cell Immunogen Atlas of Zika Virus Reveals E, NS1 and NS4 Proteins as the Vaccine Targets.Viruses · 2022Article
- Saliva collection via capillary method may underestimate arboviral transmission by mosquitoes.Parasites & vectors · 2022Article
- Serological Positivity against SelectedViruses · 2022Article
- Brevinin-2GHk, a Peptide Derived from the Skin ofViruses · 2021Article
- Construction of an infectious clone of Zika virus stably expressing an EGFP marker in a eukaryotic expression system.Virology journal · 2021Article
- Article
- Rapid Construction of an Infectious Clone of the Zika Virus, Strain ZKC2.Frontiers in microbiology · 2021Article
- TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma.Frontiers in oncology · 2021Article
- Baicalin reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal injury in type 1 diabetic mouse model.Cell cycle (Georgetown, Tex.) · 2020Article
- Inositol-Requiring Enzyme 1α Promotes Zika Virus Infection through Regulation of Stearoyl Coenzyme A Desaturase 1-Mediated Lipid Metabolism.Journal of virology · 2020Article
- Ameliorative Effect of Sinapic Acid on Dextran Sodium Sulfate- (DSS-) Induced Ulcerative Colitis in Kunming (KM) Mice.Oxidative medicine and cellular longevity · 2020Article
- Partial cross-protection between Japanese encephalitis virus genotype I and III in mice.PLoS neglected tropical diseases · 2019Article
- Characterization of Ebinur Lake Virus and Its Human Seroprevalence at the China-Kazakhstan Border.Frontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since 2015, 84 countries and territories reported evidence of vector-borne Zika Virus (ZIKV) transmission. The World Health Organization (WHO) declared that ZIKV and associated consequences especially the neurological autoimmune disorder Guillain-Barré syndrome (GBS) and microcephaly will remain a significant enduring public health challenge requiring intense action. We apply a standardization of the multi-subcutaneous dorsal inoculation method to systematically summarize clinical neurological manifestation, viral distribution, and tissue damage during the progress of viremia and systemic spread in suckling mouse models. We found that C57BL/6 and Kunming mice (KM) both showed remarkable and uniform neurologic manifestations. C57BL/6 owned the highest susceptibility and pathogenicity to the nervous system, referred to as movement disorders, with 100% incidence, while KM was an economic model for a Chinese study characterized by lower limb weakness with 62% morbidity. Slight yellow extraocular exudates were observed in BALB/c, suggesting the association with similar ocular findings to those of clinical cases. The virus distribution and pathological changes in the sera, brains, livers, kidneys, spleens, and testes during disease progression had strong regularity and uniformity, demonstrating the effectiveness and plasticity of the animal models. The successful establishment of these animal models will be conducive to expound the pathogenic mechanism of GBS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.