Evidence map›Paper›PMID 28661396›Full record

ArticleeLife2017

Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in

Aurèle Piazza, Xiaojie Cui, Michael Adrian, Frédéric Samazan, Brahim Heddi, Anh-Tuan Phan, Alain G Nicolas

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
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  12. Alternative DNA StructuresMicrobiology and molecular biology reviews : MMBR · 2021
    Review
  13. Article
  14. Article
  15. The regulation and functions of DNA and RNA G-quadruplexes.Nature reviews. Molecular cell biology · 2020
    Review
  16. Altering theBiochemistry · 2020
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Aurèle PiazzaInstitut Curie, CNRS UMR3244, PSL Research University, Paris, France.ORCID 0000-0002-7722-0955
Xiaojie CuiInstitut Curie, CNRS UMR3244, PSL Research University, Paris, France.ORCID 0000-0003-0711-8178
Michael AdrianSchool of Physical and Mathematical Sciences, Nanyang Technological University, , Singapore.
Frédéric SamazanInstitut Curie, CNRS UMR3244, PSL Research University, Paris, France.ORCID 0000-0002-4175-2810
Brahim HeddiSchool of Physical and Mathematical Sciences, Nanyang Technological University, , Singapore.ORCID 0000-0002-5535-6237
Anh-Tuan PhanSchool of Physical and Mathematical Sciences, Nanyang Technological University, , Singapore.ORCID 0000-0002-4970-3861
Alain G NicolasInstitut Curie, CNRS UMR3244, PSL Research University, Paris, France.ORCID 0000-0002-5606-7808
Centre National de la Recherche Scientifique · FRNanyang Technological University · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G-quadruplexes (G4) are polymorphic four-stranded structures formed by certain G-rich nucleic acids in vitro, but the sequence and structural features dictating their formation and function in vivo remains uncertain. Here we report a structure-function analysis of the complex hCEB1 G4-forming sequence. We isolated four G4 conformations in vitro, all of which bear unusual structural features:

Indexed as

Genomic InstabilityG-QuadruplexesMinisatellite RepeatsIntracellular Signaling Peptides and ProteinsNucleic Acid ConformationRecombinant ProteinsSaccharomyces cerevisiaeHERC5 protein, humanIntracellular Signaling Peptides and ProteinsRecombinant ProteinsbiophysicschromosomesDNA structuregenesgenetic instabilityG-quadruplexG-quadruplex ligandPif1S. cerevisiaestructural biology

Identifiers

PMID28661396
PMCPMC5491262
OpenAlexW2725768409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.