Evidence map›Paper›PMID 28660885›Full record

SynthesisJournal of human hypertension2017

Factors associated with antihypertensive medication non-adherence: a systematic review.

D M van der Laan, P J M Elders, C C L M Boons, J J Beckeringh, G Nijpels, J G Hugtenburg

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of human hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 5 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 5 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Systematic review: non-adherence and non-persistence in intravitreal treatment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Pooled it
  3. Guideline
  4. Guideline
  5. Guideline
  6. Trial
  7. Trial
  8. Trial
  9. The Impact of Antihypertensive De-escalation: A Secondary Analysis of Systolic Blood Pressure Intervention Trial (SPRINT).High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

D M van der LaanDepartment of Clinical Pharmacology and Pharmacy, VU University Medical Center, Amsterdam, The Netherlands.
P J M EldersAmsterdam Public Health research institute, VU University Medical Center, Amsterdam, The Netherlands.
C C L M BoonsDepartment of Clinical Pharmacology and Pharmacy, VU University Medical Center, Amsterdam, The Netherlands.
J J BeckeringhWestwijk Pharmaceutics BV, Kamillelaan 1, Amstelveen, The Netherlands.
G NijpelsAmsterdam Public Health research institute, VU University Medical Center, Amsterdam, The Netherlands.
J G HugtenburgDepartment of Clinical Pharmacology and Pharmacy, VU University Medical Center, Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-adherence to antihypertensive medication is the most important cause of uncontrolled blood pressure and is influenced by multiple interrelating factors. Understanding the complexity of medication non-adherence and its associated factors is important to determine intervention strategies. Therefore, a systematic review was performed aimed to identify factors associated with antihypertensive medication non-adherence. Different databases were searched for observational studies reporting on factors associated with non-adherence to antihypertensive medication. Titles, abstracts and full texts were reviewed by three researchers. Subsequently, the methodological quality of each study was assessed. Factors that were extracted from the included studies were categorised as factors with consistent or inconsistent evidence to put their potential importance into perspective. Forty-four studies were included. Higher co-payment, side effects and a poor patient-provider relationship were identified as factors with consistent evidence since consistent significant relationships were found for these factors whenever studied. The relationships between non-adherence and multiple other factors were inconsistent among the reviewed studies. However, some of these factors deserve some consideration. Since multiple potentially relevant factors were identified, patient-tailored interventions focussing on identifying and addressing patients' specific barriers to adherence are needed. Further research should clarify the influence of inconsistent factors on adherence and their potential to be addressed in interventions.

Indexed as

Medication AdherenceAdultAgedAged, 80 and overAntihypertensive AgentsBlood PressureDrug CostsFemaleHealth ExpendituresHumansHypertensionMaleMiddle AgedPhysician-Patient RelationsRisk FactorsTreatment OutcomeAntihypertensive Agents

Identifiers

PMID28660885
OpenAlexW2729798585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.