SynthesisJournal of human hypertension2017
The association between consistent licorice ingestion, hypertension and hypokalaemia: a systematic review and meta-analysis.
Synthesis in Journal of human hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Effects of Licorice Functional Components Intakes on Blood Pressure: A Systematic Review with Meta-Analysis and NETWORK Toxicology.Nutrients · 2024Pooled it
- Safety classification of herbal medicine use among hypertensive patients: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Polypharmacy and Malnutrition Management of Elderly Perioperative Patients with Cancer: A Systematic Review.Nutrients · 2021Pooled it
- Bioactive Compounds and Their Effect on Blood Pressure-A Review.Nutrients · 2020Pooled it
- Next-Generation Adaptogens: Molecular Mechanisms, Bioactive Compounds and Human Health Relevance of Selected Botanicals and Fungi.International journal of molecular sciences · 2026Review
- Article
- Bioactive Compounds from Medicinal and Edible Plants for Anti-Aging: A Systematic Review of Molecular Mechanisms, Delivery Systems, and Clinical Evidence.Foods (Basel, Switzerland) · 2026Review
- Article
- Licorice-Induced Pseudohyperaldosteronism Highlights an Underestimated Etiology of Hypertension.Kidney international reports · 2026Article
- Case Report: Delirium and complications resulting from the abuse of compound liquorice tablets.Frontiers in psychiatry · 2026Article
- Article
- Potential mechanism of traditional Chinese medicine intervention in gastric cancer: targeted regulation of autophagy.Frontiers in pharmacology · 2025Review
- Glycyrrhiza uralensis Fisch. suppresses cell migration via ROS and JAK/STAT signalling pathways inFrontiers in pharmacology · 2025Article
- Pseudohyperaldosteronism Due to Licorice: A Practice-Based Learning from a Case Series.International journal of molecular sciences · 2024Article
- The Power of Licorice (Healthcare (Basel, Switzerland) · 2023Review
- Liquorice Toxicity: A Comprehensive Narrative Review.Nutrients · 2023Review
- Dramatic recovery of left ventricular dysfunction in a patient with pseudoaldosteronism, hypokalaemia, and rhabdomyolysis: a case report.European heart journal. Case reports · 2023Article
- Lethal Arrhythmia Induced by Licorice.Journal of Korean medical science · 2023Article
- National Heart Center/Saudi Heart Association 2023 Guidelines on the Management of Hypertension.Journal of the Saudi Heart Association · 2023Article
- Herbal Approaches to Pediatric Functional Abdominal Pain.Children (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been numerous case reports of severe adverse events including deaths following chronic licorice ingestion. The aim of the present study was to evaluate the effect of chronic ingestion of licorice on blood pressure, plasma potassium, plasma renin activity and plasma aldosterone. A search of MEDLINE, PubMed, EMBASE, CENTRAL, DARE, CINAHL and Current Contents Connect was performed from inception through to 26 April 2017. Trials that included a treatment group ingesting a product containing at least 100 mg of glycyrrhizic acid daily were selected. Pooled mean changes from baseline with 95% confidence intervals were calculated for diastolic blood pressure, systolic blood pressure, plasma potassium, plasma renin activity and plasma aldosterone using a random effects model. An assessment of dose-response was also undertaken. A total of 18 studies (n=337) were included in the meta-analysis. There was a statistically significant increase in mean systolic blood pressure (5.45 mm Hg, 95% CI 3.51-7.39) and diastolic blood pressure (3.19 mm Hg, 95% CI 0.10-6.29) after chronic ingestion of a product containing glycyrrhizic acid. Plasma potassium (-0.33 mmol l
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.