ArticlePulmonary circulation
Pulmonary hypertension in patients with chronic kidney disease: invasive hemodynamic etiology and outcomes.
Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04842591 (Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation), which is not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Predictors, prevalence and prognostic role of pulmonary hypertension in patients with chronic kidney disease: a systematic review and meta-analysis.Renal failure · 2024Pooled it
- Right Heart Function in Cardiorenal Syndrome.Current heart failure reports · 2022Pooled it
- Prevalence and Mortality of Pulmonary Hypertension in ESRD: A Systematic Review and Meta-analysis.Lung · 2020Pooled it
- Prevalence of pulmonary hypertension in patients with chronic kidney disease without dialysis: a meta-analysis.International urology and nephrology · 2018Pooled it
- Disparity trends in coexisting renal failure- and pulmonary hypertension-related mortality in the United States (1999-2020): CDC WONDER database study.Annals of medicine and surgery (2012) · 2026Article
- Article
- Incident Pulmonary Hypertension and Its Risk Factors in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Association of pre-transplant pulmonary hypertension and post-transplant major adverse cardiovascular events in kidney transplant recipients: a retrospective study.BMC nephrology · 2026Article
- Reversible pre-capillary pulmonary hypertension due to long-standing arteriovenous fistula.Respiratory medicine case reports · 2026Article
- A pilot study investigating renal biomarkers in dogs with pulmonary hypertension: a comparison between cystatin-C, symmetric dimethylarginine, and creatinine.The Journal of veterinary medical science · 2025Article
- Association of Pulmonary Hypertension With Outcomes in Kidney Transplant Recipients.Kidney international reports · 2025Article
- Risk Factors for Adverse Outcomes in Connective Tissue Disease-Associated Pulmonary Hypertension.Reviews in cardiovascular medicine · 2025Review
- Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes.Nature reviews. Nephrology · 2024Review
- Pulmonary vasodilators in patients with advanced chronic kidney disease and pre-capillary pulmonary hypertension-A case series.Respirology case reports · 2024Article
- Kidney Dysfunction, Hepatic Impairment, and Lipid Metabolism Abnormalities in Patients with Precapillary Pulmonary Hypertension.Diagnostics (Basel, Switzerland) · 2024Article
- The importance of translational science within the respiratory field.Breathe (Sheffield, England) · 2024Article
- Hemodynamic response to inhaled nitric oxide in patients with pulmonary hypertension and chronic kidney disease: A retrospective cohort study.Pulmonary circulation · 2024Article
- Article
- Associations between eGFR and albuminuria with right ventricular measures: the MESA-Right Ventricle study.Clinical kidney journal · 2023Article
- From cardiorenal syndromes to cardionephrology: a reflection by nephrologists on renocardiac syndromes.Clinical kidney journal · 2023Review
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Authors and funding
8 authors.
Funding
Abstract
Pulmonary hypertension (PH) is common in patients with chronic kidney disease (CKD) and associated with increased mortality but the hemodynamic profiles, clinical risk factors, and outcomes have not been well characterized. Our objective was to define the hemodynamic profile and related risk factors for PH in CKD patients. We extracted clinical and hemodynamic data from Vanderbilt's de-identified electronic medical record on all patients undergoing right heart catheterization during 1998-2014. CKD (stages III-V) was defined by estimated glomerular filtration rate thresholds. PH was defined as mean pulmonary pressure ≥ 25 mmHg and categorized into pre-capillary and post-capillary according to consensus recommendations. In total, 4635 patients underwent catheterization: 1873 (40%) had CKD; 1518 (33%) stage 3, 230 (5%) stage 4, and 125 (3%) stage 5. PH was present in 1267 (68%) of these patients. Post-capillary (n = 965, 76%) was the predominant PH phenotype among CKD patients versus 302 (24%) for pre-capillary ( P < 0.001). CKD was independently associated with pulmonary hypertension (odds ratio = 1.4, 95% confidence interval = 1.18-1.65). Mortality among CKD patients rose with worsening stage and was significantly increased by PH status. PH is common and independently associated with mortality among CKD patients referred for right heart catheterization. Post-capillary was the most common etiology of PH. These data suggest that PH is an important prognostic co-morbidity among CKD patients and that CKD itself may have a role in the development of pulmonary vascular disease in some patients.
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