Trial reportPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2017
Prednisolone for the first rhinovirus-induced wheezing and 4-year asthma risk: A randomized trial.
Trial report in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00731575 (Viral Inception of Asthma), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Viral Inception of Asthma: Prospective Study From Infancy to School-age.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Trial
- Prednisolone for the first rhinovirus-induced wheezing and 4-year asthma risk: A randomized trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2017Trial
- Article
- The potential immunomodulatory role of human milk oligosaccharides in prevention of viral infections and development of asthma in early life.Frontiers in immunology · 2025Review
- Clinical Outcomes of Acutely Ill Children According to Cycle Threshold Values of Respiratory Viruses Detected by Multiplex PCR Testing.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Association of Asthma Risk Alleles With Acute Respiratory Tract Infections and Wheezing Illnesses in Young Children.The Journal of infectious diseases · 2023Article
- Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations.Mucosal immunology · 2022Article
- Something Is Changing in Viral Infant Bronchiolitis Approach.Frontiers in pediatrics · 2022Review
- Decoding Susceptibility to Respiratory Viral Infections and Asthma Inception in Children.International journal of molecular sciences · 2020Review
- Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma.The journal of allergy and clinical immunology. In practice · 2020Article
- Role of viruses in asthma.Seminars in immunopathology · 2020Review
- Asthma and viral infections: An intricate relationship.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Review
- Predictors of prolongation in recent-onset cough.ERJ open research · 2019Article
- Pulmonary function and bronchial reactivity 4 years after the first virus-induced wheezing.Allergy · 2019Article
- Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments.Allergy · 2019Review
- Viral infections in wheezing disorders.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Role of viral infections in the development and exacerbation of asthma in children.The Journal of allergy and clinical immunology · 2017Review
- Observational
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious findings show that corticosteroid treatment during the first acute wheezing episode may reduce recurrent wheezing in children with high rhinovirus genome load at 12-month follow-up. Longer-term effects have not been investigated prospectively.
methodsAfter PCR confirmation of rhinovirus from nasopharyngeal aspirate, 79 children with the first acute wheezing episode were randomized to receive orally prednisolone or placebo for 3 days. The initiation of asthma control medication before the age of 5 years was confirmed from medical record and/or from parental interview. The outcome was the time to initiation of regular asthma control medication. Interaction analysis examined rhinovirus genome load.
resultsFifty-nine (75%) children completed the follow-up. Asthma control medication was initiated in 40 (68%) children at the median age of 20 months. Overall, prednisolone did not affect the time to initiation of asthma control medication when compared to placebo (P=.99). Rhinovirus load modified the effect of prednisolone regarding the time to initiation of asthma control medication (P-value for interaction=.04). In children with high rhinovirus load (>7000 copies/mL; n=23), the risk for initiation of medication was lower in the prednisolone group compared to the placebo group (P=.05). In the placebo group, asthma medication was initiated to all children with high rhinovirus load (n=9) during the 14 months after the first wheezing episode.
conclusionsOverall, prednisolone did not affect the time to initiation of asthma control medication when compared to placebo. However, prednisolone may be beneficial in first-time wheezing children whose episode was severe and associated with high rhinovirus load. (ClinicalTrials.gov, NCT00731575).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.