SynthesisInternational journal of clinical pharmacy2017
Influence of dexmedetomidine on cardiac complications in non-cardiac surgery: a meta-analysis of randomized trials.
Synthesis in International journal of clinical pharmacy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Perioperative dexmedetomidine reduces the risk of postoperative complications in high-risk patients undergoing non-cardiac surgery: A randomized controlled trial.Chinese medical journal · 2026Trial
- Protocol: dexmedetomidine on myocardial injury after noncardiac surgery-a multicenter, double-blind, controlled trial.Perioperative medicine (London, England) · 2023Article
- Acute Kidney Injury and 3-Year Mortality in Elderly Patients After Non-cardiac Surgery.Frontiers in medicine · 2022Article
- Dexmedetomidine and clinical outcomes of non-cardiac surgery.Journal of anesthesia · 2019Article
- Response to letter to the editor.Journal of anesthesia · 2019Article
- A Response Surface Analysis of the Combination of Dexmedetomidine and Sufentanil for Attenuating the Haemodynamic Response to Endotracheal Intubation.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The cardiac protection of dexmedetomidine (Dex) in peri-operative period of patients with non-cardiac surgery is still controversial. Aim of the Review We aimed to evaluate the influence of Dex on cardiac complications in peri-operative period of non-cardiac surgery by using a meta-analysis. Methods PubMed, Embase, the Cochrane library and Springer databases were searched for relevant studies. Patients in the eligible studies were divided into Dex group and placebo group. Relative risk (RR) and the 95 % confidence interval (CI) were calculated to evaluate the outcomes including all-cause mortality, myocardial infarction, myocardial ischaemia, hypotension and bradycardia. Subgroup analysis was performed based on the dosage of Dex. Publication bias was assessed by Egger's test. Results Twenty double-blind randomized controlled trials containing 1157 patients were included in this meta-analysis. The pooled results showed no significant difference between Dex group and placebo group in peri-operative myocardial infarction, myocardial ischaemia and all-cause mortality. However, Dex group showed higher risk of hypotension (RR = 1.46, 95 % CI 1.07, 2.01) and bradycardia (RR = 1.98, 95 % CI 1.33, 2.95) than that of placebo group. In addition, significant publication bias was found among studies involving hypotension and bradycardia. In subgroup analysis, the risk of bradycardia was significantly higher in 1.0 μg/kg Dex group than that in placebo group. Besides, a higher risk of hypotension in 0.5 μg/kg Dex group than that in placebo group was found. Conclusions Dex supplement might not reduce the risk of cardiac complications but increases the risk of hypotension and bradycardia in peri-operative period of patients who underwent non-cardiac surgeries.
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