ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2018
Identity Elements of tRNA as Derived from Information Analysis.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Mistranslating tRNA variants have anticodon- and sex-specific impacts on Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Article
- Impact of tRNA-induced proline-to-serine mistranslation on the transcriptome of Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Mistranslating tRNA variants have anticodon- and sex-specific impacts onbioRxiv : the preprint server for biology · 2024Article
- Impact of tRNA-induced proline-to-serine mistranslation on the transcriptome ofbioRxiv : the preprint server for biology · 2024Article
- tRNA shape is an identity element for an archaeal pyrrolysyl-tRNA synthetase from the human gut.Nucleic acids research · 2024Article
- Symmetrical distributions of aminoacyl-tRNA synthetases during the evolution of the genetic code.Theory in biosciences = Theorie in den Biowissenschaften · 2023Article
- The tRNA identity landscape for aminoacylation and beyond.Nucleic acids research · 2023Review
- Structural and Genetic Determinants of Convergence in the Drosophila tRNA Structure-Function Map.Journal of molecular evolution · 2021Article
- The Ancient History of Peptidyl Transferase Center Formation as Told by Conservation and Information Analyses.Life (Basel, Switzerland) · 2020Article
- Information theory unveils the evolution of tRNA identity elements in the three domains of life.Theory in biosciences = Theorie in den Biowissenschaften · 2020Article
- Experimental solutions to problems defining the origin of codon-directed protein synthesis.Bio Systems · 2019Review
- Intrinsic Properties of tRNA Molecules as Deciphered via Bayesian Network and Distribution Divergence Analysis.Life (Basel, Switzerland) · 2018Article
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Authors and funding
2 authors.
Funding
Abstract
The decipherment of the tRNA's operational code, known as the identity problem, requires the location of the sites in the tRNA structure that are involved in their correct recognition by the corresponding aminoacyl-tRNA synthetase. In this work, we determine the identity elements of each tRNA isoacceptor by means of the variation of information measure from information theory. We show that all isoacceptors exhibit sites associated with some bases of the anticodon. These sites form clusters that are scattered along the tRNA structure. The clusters determine the identity elements of each tRNA. We derive a catalogue of clustered sites for each tRNA that expands previously reported elements.
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Registered trials
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