Evidence map›Paper›PMID 28660376›Full record

ArticleJournal of bone and mineral metabolism2018

Bone metabolism markers and angiogenic cytokines as regulators of human hematopoietic stem cell mobilization.

Pantelis Tsirkinidis, Evangelos Terpos, Georgios Boutsikas, Athanasios Papatheodorou, Konstantinos Anargyrou, Eleni Lalou, Aglaia Dimitrakopoulou, Christina Kalpadakis, Konstantinos Konstantopoulos, Marina Siakantaris and 5 more

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In one paragraph

Article in Journal of bone and mineral metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Pantelis TsirkinidisDepartment of Hematology, 401 General Army Hospital of Athens, Athens, Greece.
Evangelos TerposDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Georgios BoutsikasDepartment of Hematology, 251 General Air Force Hospital, Athens, Greece.
Athanasios PapatheodorouDepartment of Medical Research, 251 General Air Force Hospital, Athens, Greece.
Konstantinos AnargyrouDepartment of Hematology, 251 General Air Force Hospital, Athens, Greece.
Eleni LalouDepartment of Hematology and Bone Marrow Transplantation, School of Medicine, National and Kapodistrian University of Athens, 17, Agiou Thoma Street, 11527, Athens, Greece.
Aglaia DimitrakopoulouDepartment of Immunology Research and Flow Cytometry, 'Laiko' General Hospital of Athens, Athens, Greece.
Christina KalpadakisDepartment of Hematology, School of Medicine, University of Crete, Herakleion, Greece.
Konstantinos KonstantopoulosDepartment of Hematology and Bone Marrow Transplantation, School of Medicine, National and Kapodistrian University of Athens, 17, Agiou Thoma Street, 11527, Athens, Greece.
Marina Siakantaris1st Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Panayiotis Panayiotidis1st Propedeutic Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Gerassimos PangalisDepartment of Hematology, Psychicon Branch, Athens Medical Center, Athens, Greece.
Marie-Christine Kyrtsonis1st Propedeutic Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Theodoros VassilakopoulosDepartment of Hematology and Bone Marrow Transplantation, School of Medicine, National and Kapodistrian University of Athens, 17, Agiou Thoma Street, 11527, Athens, Greece.
Maria K AngelopoulouDepartment of Hematology and Bone Marrow Transplantation, School of Medicine, National and Kapodistrian University of Athens, 17, Agiou Thoma Street, 11527, Athens, Greece. mkangelop@gmail.com.ORCID http://orcid.org/0000-0002-1596-3630
National and Kapodistrian University of Athens · GRHellenic Air Force · GR401 General Military Hospital of Athens · GRAthens Medical Center · GRLaiko General Hospital of Athens · GRUniversity of Crete · GR

Funding

Acquisition of Sony Biotechnology iCyt Synergy SY3200 BSC Cell SorterS10OD016230 · OD · JOHNS HOPKINS UNIVERSITY · PI MCCAFFERY, J. MICHAEL · 2014 to 2014
$520k
NIH HHS S10 OD016230
6 · The paper itself

Abstract

Hematopoietic stem cell (HSC) mobilization involves cleavage of ligands between HSC and niche components. However, there are scarce data regarding the role of bone cells in human HSC mobilization. We studied biochemical markers of bone metabolism and angiogenic cytokines during HSC mobilization in 46 patients' sera with lymphoma and multiple myeloma, by ELISA. Significant changes between pre-mobilization and collection samples were found: (1) Bone alkaline phosphatase (BALP) increased, indicating augmentation of bone formation; (2) Receptor activator of Nf-κB ligand/osteoprotegerin ratio (RANKL/OPG) increased, showing osteoclastic differentiation and survival; however, there was no evidence of increased osteoclastic activity; and (3) Angiopoietin-1/Angiopoietin-2 ratio (ANGP-1/ANGP-2) decreased, consistent with vessel destabilization. Poor mobilizers had significantly higher carboxy-terminal telopeptide of collagen type I (CTX) and lower ANGP-1 at pre-mobilization samples, compared to good ones. CTX, amino-terminal telopeptide of collagen type I (NTX) and ANGP-1 pre-mobilization levels correlated significantly with circulating CD34

Indexed as

Hematopoietic Stem Cell MobilizationNeovascularization, PhysiologicAdolescentAdultAgedBiomarkersBone and BonesCytokinesFemaleHumansMaleMiddle AgedOsteoblastsOsteoclastsOsteoprotegerinRANK LigandBiomarkersCytokinesOsteoprotegerinRANK LigandAngiopoietinsBone cellsBone markersHematopoietic stem cellsMobilization

Identifiers

PMID28660376
OpenAlexW2727332568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.