Evidence map›Paper›PMID 28660286›Full record

ArticleThe Journal of membrane biology2017

Hydrocinnamic Acid Inhibits the Currents of WT and SQT3 Syndrome-Related Mutants of Kir2.1 Channel.

Shuxi Ren, Chunli Pang, Yayue Huang, Chengfen Xing, Yong Zhan, Hailong An

Abstract read
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Article in The Journal of membrane biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shuxi RenKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China.
Chunli PangKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China.
Yayue HuangKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China.
Chengfen XingKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China.
Yong ZhanKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China. zhany@hebut.edu.cn.
Hailong AnKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China. hailong_an@hebut.edu.cn.ORCID http://orcid.org/0000-0001-7947-357X
Hebei University of Technology · CN

Funding

Natural Science Found for Distinguished Young Scholars of the Hebei Province of China C2015202340the Foundation for Outstanding Talents of Hebei Province of China C201400305the National Natural Science Foundation of China 11175055the National Natural Science Foundation of China 11247010the National Natural Science Foundation of China 11347017the National Natural Science Foundation of China 11475053the National Natural Science Foundation of China 31400711the Natural Science Found for Distinguished Young Scholars of the Hebei Province of China C2013202244
6 · The paper itself

Abstract

Gain of function in mutations, D172N and E299V, of Kir2.1 will induce type III short QT syndrome. In our previous work, we had identified that a mixture of traditional Chinese medicine, styrax, is a blocker of Kir2.1. Here, we determined a monomer, hydrocinnamic acid (HA), as the effective component from 18 compounds of styrax. Our data show that HA can inhibit the currents of Kir2.1 channel in both excised inside-out and whole-cell patch with the IC

Indexed as

Arrhythmias, CardiacHeart Defects, CongenitalMolecular Docking SimulationMutationPhenylpropionatesPotassium Channels, Inwardly RectifyingHeart Conduction SystemHEK293 CellsHumansMembrane PotentialsPhosphatidylinositol 4,5-Diphosphate3-phenylpropionic acidKCNJ2 protein, humanPhenylpropionatesPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Inwardly RectifyingHydrocinnamic acidInhibitorKir2.1 channelPIP2SQT3

Identifiers

PMID28660286
OpenAlexW2727973154

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.