ArticleeNeuro
Avoidant Responses to Interpersonal Provocation Are Associated with Increased Amygdala and Decreased Mentalizing Network Activity.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A meta-analysis on shared and distinct neural correlates of the decision-making underlying altruistic and retaliatory punishment.Human brain mapping · 2021Pooled it
- Neural networks of aggression: ALE meta-analyses on trait and elicited aggression.Brain structure & function · 2019Pooled it
- Longitudinal microstructural changes in 18 amygdala nuclei resonate with cortical circuits and phenomics.Communications biology · 2024Article
- The Predictive Role of the Posterior Cerebellum in the Processing of Dynamic Emotions.Cerebellum (London, England) · 2024Article
- Neuroanatomical correlates of aggressiveness: a case-control voxel- and surface-based morphometric study.Brain structure & function · 2024Article
- A neuroimaging study of interpersonal distance in identical and fraternal twins.Human brain mapping · 2022Article
- Social Interaction With an Anonymous Opponent Requires Increased Involvement of the Theory of Mind Neural System: An fMRI Study.Frontiers in behavioral neuroscience · 2022Article
- Low competitive status elicits aggression in healthy young men: behavioural and neural evidence.Social cognitive and affective neuroscience · 2021Article
- Neural mechanisms of intimate partner aggression.Biological psychology · 2021Article
- Neural Correlates of Decisions in Quasi-Realistic, Affective Social Interactions in Individuals With Violence-Related Socialization.Frontiers in behavioral neuroscience · 2021Article
- Anger provocation increases limbic and decreases medial prefrontal cortex connectivity with the left amygdala in reactive aggressive violent offenders.Brain imaging and behavior · 2019Article
- Intersections and Divergences Between Empathizing and Mentalizing: Development, Recent Advancements by Neuroimaging and the Future of Animal Modeling.Frontiers in behavioral neuroscience · 2019Article
- Hit or Run: Exploring Aggressive and Avoidant Reactions to Interpersonal Provocation Using a Novel Fight-or-Escape Paradigm (FOE).Frontiers in behavioral neuroscience · 2017Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When intentionally pushed or insulted, one can either flee from the provoker or retaliate. The implementation of such fight-or-flight decisions is a central aspect in the genesis and evolution of aggression episodes, yet it is usually investigated only indirectly or in nonsocial situations. In the present fMRI study, we aimed to distinguish brain regions associated with aggressive and avoidant responses to interpersonal provocation in humans. Participants (thirty-six healthy young women) could either avoid or face a highly (HP) and a lowly (LP) provoking opponent in a competitive reaction time task: the fight-or-escape (FOE) paradigm. Subjects avoided the HP more often, but retaliated when facing her. Moreover, they chose to fight the HP more quickly, and showed increased heart rate (HR) right before confronting her. Orbitofrontal cortex (OFC) and sensorimotor cortex were more active when participants decided to fight, whereas the mentalizing network was engaged when deciding to avoid. Importantly, avoiding the HP relative to the LP was associated with both higher activation in the right basolateral amygdala and lower relative activity in several mentalizing regions [e.g., medial and inferior frontal gyrus (IFG), temporal-parietal junction (TPJ)]. These results suggest that avoidant responses to provocation might result from heightened threat anticipation and are associated with reduced perspective taking. Furthermore, our study helps to reconcile conflicting findings on the role of the mentalizing network, the amygdala, and the OFC in aggression.
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