Evidence map›Paper›PMID 28660246›Full record

ArticleeNeuro

GABA-B Controls Persistent Na

Ping Li, Richard Stewart, Alice Butler, Ana Laura Gonzalez-Cota, Steve Harmon, Lawrence Salkoff

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Poly-dipeptides produced fromProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  2. Review
  3. Activation of GABAJournal of neurophysiology · 2020
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ping LiDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-2827-6925
Richard StewartDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110.
Alice ButlerDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110.
Ana Laura Gonzalez-CotaDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110.
Steve HarmonDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110.
Lawrence SalkoffDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-7400-6550
Washington University in St. Louis · US

Funding

Testing a Novel Push-Pull Mechanism for Ca2+-Dependent Coupling in BK ChannelsR01GM114694 · NIGMS · WASHINGTON UNIVERSITY · PI MAGLEBY, KARL L, SALKOFF, LAWRENCE B · 2016 to 2019
$1.9M
ARE SODIUM-ACTIVATED POTASSIUM CHANNELS THE "GATE-KEEPERS" OF SYNAPTIC INTEGRATION?R21MH107955 · NIMH · WASHINGTON UNIVERSITY · PI SALKOFF, LAWRENCE B · 2015 to 2016
$419k
AN OVERLOOKED K+ CURRENT REPOLARIZES ACTION POTENTIALS THROUGHOUT THE BRAINR21NS088611 · NINDS · WASHINGTON UNIVERSITY · PI SALKOFF, LAWRENCE B · 2015 to 2016
$419k
NIGMS NIH HHS R01 GM114694NIMH NIH HHS R21 MH107955NINDS NIH HHS R21 NS088611
6 · The paper itself

Abstract

The GABA-B receptor is densely expressed throughout the brain and has been implicated in many CNS functions and disorders, including addiction, epilepsy, spasticity, schizophrenia, anxiety, cognitive deficits, and depression, as well as various aspects of nervous system development. How one GABA-B receptor is involved in so many aspects of CNS function remains unanswered. Activation of GABA-B receptors is normally thought to produce inhibitory responses in the nervous system, but puzzling contradictory responses exist. Here we report that in rat mitral cells of the olfactory bulb, GABA-B receptor activation inhibits both the persistent sodium current (INa

Indexed as

AnimalsCations, MonovalentCells, CulturedMembrane PotentialsNeuronsOlfactory BulbOocytesPatch-Clamp TechniquesPotassiumPotassium ChannelsRats, Sprague-DawleyReceptors, GABA-BSodiumXenopus laevisCations, MonovalentPotassiumPotassium ChannelsReceptors, GABA-BSodiumBaclofenGABA-Bmitral cellolfactory bulbpersistent sodium currentpotassium channelSlickSLO2

Identifiers

PMID28660246
PMCPMC5482115
OpenAlexW2621628303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.