Evidence map›Paper›PMID 28660218›Full record

ArticleAsia Oceania journal of nuclear medicine & biology2017

Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging with

Naohiro Tsuyuguchi, Yuzo Terakawa, Takehiro Uda, Kosuke Nakajo, Yonehiro Kanemura

3 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Asia Oceania journal of nuclear medicine & biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05553041 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of 18F-Fluciclovine PET-MRI to Differentiate Tumor Progression From Post-treatment Changes in Pediatric High-grade Glioma (HGG)

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2024 to 2027Enrolled30ConditionsGlioma, High Grade Glioma, Glioma, Malignant, Glioma IntracranialArms18F-Fluciclovine PET-MRI
NCT05554302 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis

TypeinterventionalSponsorBaptist Health South FloridaRan2023 to 2030Enrolled20ConditionsBrain Metastases, Brain CancerArms18F-Fluciclovine
NCT05555550 early_phase1recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of 18F-Fluciclovine PET-MRI as a Biomarker of Response in Pediatric and Young Adult Patients With Low Grade Gliomas (LGG)

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2026 to 2027Enrolled30ConditionsGlioma, Low-grade Glioma, Low Grade Glioma of Brain, Glioma, MalignantArms18F-Fluciclovine
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Clinical Practice Guidelines forAnnals of nuclear medicine · 2025
    Guideline
  2. Trial
  3. Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Article
  5. CD98 Light Chain LAT1 Tracers in PET-CT Diagnosis of Cancer Patients.Anti-cancer agents in medicinal chemistry · 2026
    Review
  6. Physiological biodistribution ofFrontiers in nuclear medicine · 2026
    Article
  7. Surgical neurology international · 2026
    Article
  8. Article
  9. Potential impact of [Radiation oncology (London, England) · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Impact of [Annals of nuclear medicine · 2024
    Article
  18. EJNMMI reports · 2024
    Article
  19. Diagnostic accuracy of anti-3-[European journal of nuclear medicine and molecular imaging · 2024
    Article
  20. Diagnostic Accuracy of PET withDiagnostics (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Naohiro TsuyuguchiDepartment of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Yuzo TerakawaDepartment of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Takehiro UdaDepartment of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Kosuke NakajoDepartment of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Yonehiro KanemuraDepartment of neurosyrgery, Kansai Molecular Diagnosis Network for CNS Tumors, Osaka National Hospital, Osaka, Japan.
Osaka City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectives

methodsSix consecutive patients (four male, two female), who were clinically suspected of having high- or low-grade glioma, received both FACBC-PET and MET-PET within a two-week interval. T1-weighted, contrast-enhanced, T1-weighted, and fluid-attenuated inversion recovery magnetic resonance imaging was performed to assist with subsequent tissue resection. Visual findings and semi-quantitative analyses of FACBC and MET uptake, using standardized uptake values (SUVs) and lesion-to-contralateral normal brain tissue (LN) ratios, were evaluated to compare PET images.

resultsSUVs for FACBC were lower than those for MET in the non-lesion cerebral cortex, brain stem, and cerebellar hemisphere. There was a weak positive correlation between FACBC and MET uptake in glioma tissue, although L/N ratios for FACBC were higher than those for MET in all the cases.

conclusionFACBC-PET showed higher contrast than MET-PET by both visual and semi-quantitative analyses and may therefore provide better assessment for the detection of glioma. This study was registered as clinical trial (No. JapicCTI-132289).

Indexed as

11C-Methionine18F-FluciclovineGliomaPositron emission tomography

Identifiers

PMID28660218
PMCPMC5482923
OpenAlexW2621309304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.