Evidence map›Paper›PMID 28660215›Full record

ReviewJournal of immunology research2017

Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study.

Caner Süsal, Alexander Fichtner, Burkhard Tönshoff, Arianeb Mehrabi, Martin Zeier, Christian Morath

Abstract readReview
In one paragraph

Review in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caner SüsalTransplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-2521-8201
Alexander FichtnerDepartment of Pediatrics I, University Children's Hospital, University of Heidelberg, Heidelberg, Germany.
Burkhard TönshoffDepartment of Pediatrics I, University Children's Hospital, University of Heidelberg, Heidelberg, Germany.
Arianeb MehrabiDepartment of Transplantation and General Surgery, University of Heidelberg, Heidelberg, Germany.
Martin ZeierDivision of Nephrology, University of Heidelberg, Heidelberg, Germany.
Christian MorathDivision of Nephrology, University of Heidelberg, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we summarize our recent findings from the international Collaborative Transplant Study (CTS) and Heidelberg Transplant Center regarding the role of HLA antibodies in kidney transplantation and their application into the clinical routine. Based on the antibody findings from the CTS serum study, an algorithm was developed in 2006 for the transplantation of high-risk sensitized patients at the Heidelberg Transplant Center which includes seven different pre- and posttransplant measures. Using this algorithm, the number of transplantations could be increased in high-risk presensitized patients and the previously existing impact of antibodies on graft survival could greatly be diminished but not totally eliminated. More recent findings led to the hypothesis that T cell help from a preactivated immune system supports the harmful effects of pretransplant donor-specific HLA antibodies that otherwise disappear in many cases after transplantation without any consequence.

Indexed as

Enzyme-Linked Immunosorbent AssayFemaleGraft RejectionGraft SurvivalHistocompatibility TestingHLA AntigensHumansImmunizationImmunologic FactorsIntersectoral CollaborationIsoantibodiesKidney TransplantationMaleTissue DonorsHLA AntigensImmunologic FactorsIsoantibodies

Identifiers

PMID28660215
PMCPMC5474267

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.