Evidence map›Paper›PMID 28660047›Full record

ArticleChemical science2016

DNA orientation-specific adhesion and patterning of living mammalian cells on self-assembled DNA monolayers.

Shaopeng Wang, Xiaoqing Cai, Lihua Wang, Jiang Li, Qian Li, Xiaolei Zuo, Jiye Shi, Qing Huang, Chunhai Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. DNA storage: The future direction for medical cold data storage.Synthetic and systems biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shaopeng WangDivision of Physical Biology & Bioimaging Center , Shanghai Synchrotron Radiation Facility , CAS Key Laboratory of Interfacial Physics and Technology , Shanghai Institute of Applied Physics , Chinese Academy of Sciences , Shanghai , 201800 , China . Email: zuoxiaolei@sinap.ac.cn.
Xiaoqing CaiDivision of Physical Biology & Bioimaging Center , Shanghai Synchrotron Radiation Facility , CAS Key Laboratory of Interfacial Physics and Technology , Shanghai Institute of Applied Physics , Chinese Academy of Sciences , Shanghai , 201800 , China . Email: zuoxiaolei@sinap.ac.cn.
Lihua WangDivision of Physical Biology & Bioimaging Center , Shanghai Synchrotron Radiation Facility , CAS Key Laboratory of Interfacial Physics and Technology , Shanghai Institute of Applied Physics , Chinese Academy of Sciences , Shanghai , 201800 , China . Email: zuoxiaolei@sinap.ac.cn.
Jiang LiDivision of Physical Biology & Bioimaging Center , Shanghai Synchrotron Radiation Facility , CAS Key Laboratory of Interfacial Physics and Technology , Shanghai Institute of Applied Physics , Chinese Academy of Sciences , Shanghai , 201800 , China . Email: zuoxiaolei@sinap.ac.cn.
Qian LiDivision of Physical Biology & Bioimaging Center , Shanghai Synchrotron Radiation Facility , CAS Key Laboratory of Interfacial Physics and Technology , Shanghai Institute of Applied Physics , Chinese Academy of Sciences , Shanghai , 201800 , China . Email: zuoxiaolei@sinap.ac.cn.
Xiaolei ZuoDivision of Physical Biology & Bioimaging Center , Shanghai Synchrotron Radiation Facility , CAS Key Laboratory of Interfacial Physics and Technology , Shanghai Institute of Applied Physics , Chinese Academy of Sciences , Shanghai , 201800 , China . Email: zuoxiaolei@sinap.ac.cn.
Jiye ShiDivision of Physical Biology & Bioimaging Center , Shanghai Synchrotron Radiation Facility , CAS Key Laboratory of Interfacial Physics and Technology , Shanghai Institute of Applied Physics , Chinese Academy of Sciences , Shanghai , 201800 , China . Email: zuoxiaolei@sinap.ac.cn.
Qing HuangDivision of Physical Biology & Bioimaging Center , Shanghai Synchrotron Radiation Facility , CAS Key Laboratory of Interfacial Physics and Technology , Shanghai Institute of Applied Physics , Chinese Academy of Sciences , Shanghai , 201800 , China . Email: zuoxiaolei@sinap.ac.cn.
Chunhai FanDivision of Physical Biology & Bioimaging Center , Shanghai Synchrotron Radiation Facility , CAS Key Laboratory of Interfacial Physics and Technology , Shanghai Institute of Applied Physics , Chinese Academy of Sciences , Shanghai , 201800 , China . Email: zuoxiaolei@sinap.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To better understand cell behaviors on substrates, the precise control of density and orientation of cell-specific ligands remains a great challenge. In this study, we established an easy-to-use approach to manipulate the adhesion and patterning of mammalian cells on gold substrates. We prepared DNA self-assembled monolayers (DNA-SAMs) on gold substrates and found that the sequence-specific orientation of DNA-SAMs played an important role in modulating cell adhesion. We also found that the DNA-SAMs on gold substrates could be used as a potentially universal cell culture substrate, which showed properties similar to cationic polymers (

Identifiers

PMID28660047
PMCPMC5477012

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.