ReviewGastroenterology research and practice2017
Esophageal Cancer Metastases to Unexpected Sites: A Systematic Review.
Review in Gastroenterology research and practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Case Report: Small bowel metastasis from esophageal squamous cell carcinoma: a case series and systematic review of clinical characteristics, tropism, and survival outcomes.Frontiers in immunology · 2026Pooled it
- The role of surgical treatment in isolated organ recurrence of esophageal cancer-a systematic review of the literature.World journal of surgical oncology · 2018Pooled it
- Detachable string magnetically controlled capsule endoscopy for the noninvasive diagnosis of esophageal diseases: A prospective, blind clinical study.World journal of gastroenterology · 2024Trial
- Ocular metastasis from esophageal cancer: a systematic review and pooled analysis of individual-level case data.Surgery today · 2026Review
- Case Report: A rare case of esophageal squamous cell carcinoma with metastases to the pancreas and stomach.Frontiers in oncology · 2026Article
- An Atypical Case of Metastatic Esophageal Adenocarcinoma Causing Biliary Obstruction and Duodenal Infiltration Requiring EUS-Guided Choledochoduodenostomy.Clinical medicine insights. Case reports · 2026Article
- Endoscopic ultrasound‑guided fine‑needle aspiration for unresectable pancreatic metastasis of esophageal squamous cell carcinoma: A case report and literature review.Oncology letters · 2025Article
- Unveiling Another Dimension: Advanced Visualization of Cancer Invasion and Metastasis via Micro-CT Imaging.Cancers · 2025Article
- Small bowel metastasis during organ preservation in patients with esophageal squamous cell carcinoma: case report and literature review.Frontiers in oncology · 2025Article
- Rare metastasis of the urinary bladder from esophageal squamous cell carcinoma: a case report.Frontiers in oncology · 2025Article
- Identifying the unlikely suspect: A massive patellar metastasis from esophageal squamous cell carcinoma-A case report.Radiology case reports · 2025Article
- Nomogram model for predicting long-term survival in esophageal cancer patients with metastasis after treatment: a SEER-based study.Journal of thoracic disease · 2024Article
- Pancreatic Metastases of Esophageal Squamous Cell Carcinoma: A Case Report and Review of the Literature.Diagnostics (Basel, Switzerland) · 2024Article
- The Uncharted Territories of Esophageal Cancer with Cardiac and Skeletal Muscle Metastasis: A Case Report and Literature Review.Medicina (Kaunas, Lithuania) · 2024Review
- A Rare Case of Ileocecal Lymph Node Recurrence After Surgery in Siewert's Classification Type I Esophagogastric Junction Adenocarcinoma.The American journal of case reports · 2024Article
- Gastroesophageal Junction Adenocarcinoma With Skeletal Muscle Metastases: A Case Report and Literature Review.Cureus · 2024Article
- The Chest Wall Mass of Unknown Origin: A Rare Presentation of Esophageal Adenocarcinoma.Cureus · 2024Article
- Intraoperative Facial Nerve Involvement in Parotid Tumours - A Retrospective Analysis in a Tertiary Care Centre.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Esophageal Adenocarcinoma Presenting as an Isolated Brain Lesion 6 Years After Treatment.ACG case reports journal · 2024Article
- Metastatic Esophageal Adenocarcinoma Presenting as Neck Dermal Metastasis.Case reports in dermatological medicine · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most common pattern of esophageal cancer metastases (ECM) is to the lymph nodes, lung, liver, bones, adrenal glands, and brain. On the other hand, unexpected metastasis (UM) spread to uncommon sites has increasingly reported and consequently affected the pathway of diagnosis, staging, and management. Using the PubMed database, a systematic search of the following headings "Esophageal" and "Metastasis" or "Metastases" was performed, 10049 articles were identified, and the articles were included if they demonstrated unexpected ECM. 84% of cases were men with an average age of 60.7 years. EC was located in the lower third in 65%. Two-thirds of the UM originated from the lower esophagus, and the two major histological types were adenocarcinoma 40% and squamous cell carcinoma 60%. Metastases were disseminated toward five main anatomical sites: the head and neck (42%), thoracic (17%), abdomen and pelvis (25%), extremities (9%), and multiple skin and muscle metastases (7%). The EC metastases were found to be synchronous 42% and metachronous 58%, isolated in 53.5% and multiple in 46.5%. The overall survival rate was 10.2 months. Since distant metastases are responsible for most EC-related deaths, understanding of ECM dissemination patterns needs more extensive studies. These critical data are the cornerstone of optimal cancer approach and treatment.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.