ReviewFrontiers in plant science2017
The Multitalented MEDIATOR25.
Review in Frontiers in plant science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- RDO3 REPRESSOR 27, a new MED25 allele, regulates seed dormancy dependent on DOG1 and ABA pathways in Arabidopsis.Planta · 2026Article
- When MED16 Meets Plant Growth, Development, and Stress Response.International journal of molecular sciences · 2026Review
- Bioinformatic Analyses of the Ataxin-2 Family Since Algae Emphasize Its Small Isoforms, Large Chimerisms, and the Importance of Human Exon 1B as Target of Therapies to Prevent Neurodegeneration.International journal of molecular sciences · 2026Article
- Genetic, Clinical and Neuroradiological Spectrum of MED-Related Disorders: An Updated Review.Genes · 2025Review
- A semidominant point mutation of Mediator tail subunit MED5b in Arabidopsis leads to altered enrichment of H3K27me3 and reduced expression of targets of MYC2.G3 (Bethesda, Md.) · 2025Article
- A multiprotein regulatory module, MED16-MBR1&2, controls MED25 homeostasis during jasmonate signaling.Nature communications · 2025Article
- Environmental genome-wide association studies across precipitation regimes reveal that the E3 ubiquitin ligase MBR1 regulates plant adaptation to rainy environments.Plant communications · 2024Article
- Alternative splicing dynamically regulates common carp embryogenesis under thermal stress.BMC genomics · 2024Article
- Regulation of Flowering Time by Environmental Factors in Plants.Plants (Basel, Switzerland) · 2023Review
- The Mediator complex subunit MED25 interacts with HDA9 and PIF4 to regulate thermomorphogenesis.Plant physiology · 2023Article
- SlBBX20 attenuates JA signalling and regulates resistance to Botrytis cinerea by inhibiting SlMED25 in tomato.Plant biotechnology journal · 2023Article
- The Mutation of Rice MEDIATOR25, OsMED25, Induces Rice Bacterial Blight Resistance through Altering Jasmonate- and Auxin-Signaling.Plants (Basel, Switzerland) · 2022Article
- Genome-wide identification, comprehensive characterization of transcription factors, cis-regulatory elements, protein homology, and protein interaction network of DREB gene family inFrontiers in plant science · 2022Article
- Jasmonic Acid Signaling and Molecular Crosstalk with Other Phytohormones.International journal of molecular sciences · 2021Review
- Structural insights into Arabidopsis ethylene response factor 96 with an extended N-terminal binding to GCC box.Plant molecular biology · 2020Article
- Mediator Subunit MED25 Physically Interacts with PHYTOCHROME INTERACTING FACTOR4 to Regulate Shade-Induced Hypocotyl Elongation in Tomato.Plant physiology · 2020Article
- Mediator Complex: A Pivotal Regulator of ABA Signaling Pathway and Abiotic Stress Response in Plants.International journal of molecular sciences · 2020Review
- Multivalent and Bidirectional Binding of Transcriptional Transactivation Domains to the MED25 Coactivator.Biomolecules · 2020Article
- FIT, a regulatory hub for iron deficiency and stress signaling in roots, and FIT-dependent and -independent gene signatures.Journal of experimental botany · 2020Review
- Interaction map of Arabidopsis Mediator complex expounding its topology.Nucleic acids research · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multi-subunit Mediator complex, which links DNA-bound transcription factors to RNA Pol II during transcription, is an essential regulator of gene expression in all eukaryotes. Individual subunits of the Mediator complex integrate numerous endogenous and exogenous signals. In this paper, diverse regulatory functions performed by MEDIATOR25 (MED25), one of the subunits of the plant Mediator complex are reviewed. MED25 was first identified as a regulator of flowering time and named PHYTOCHROME AND FLOWERING TIME1 (PFT1). Since then, MED25 has been implicated in a range of other plant functions that vary from hormone signaling (JA, ABA, ethylene, and IAA) to biotic and abiotic stress tolerance and plant development. MED25 physically interacts with transcriptional activators (e.g., AP2/ERFs, MYCs, and ARFs), repressors (e.g., JAZs and Aux/IAAs), and other Mediator subunits (MED13 and MED16). In addition, various genetic and epigenetic interactions involving MED25 have been reported. These features make MED25 one of the most multifunctional Mediator subunits and provide new insights into the transcriptional control of gene expression in plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.