ArticleFrontiers in psychiatry2017
Risk-Conferring Glutamatergic Genes and Brain Glutamate Plus Glutamine in Schizophrenia.
Article in Frontiers in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis.Molecular psychiatry · 2023Pooled it
- Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.Nature communications · 2020Pooled it
- The genome-wide supported CACNA1C gene polymorphisms and the risk of schizophrenia: an updated meta-analysis.BMC medical genetics · 2020Pooled it
- Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial.JAMA psychiatry · 2018Trial
- hiPSC-derived cortical neurons from ADHD individuals reveal dysregulated glutamatergic development.Molecular psychiatry · 2026Article
- Treatment resistance NMDA receptor pathway polygenic score is associated with brain glutamate in schizophrenia.Schizophrenia research · 2023Article
- The association between peripheral inflammation, brain glutamate and antipsychotic response in Schizophrenia: Data from the STRATA collaboration.Brain, behavior, and immunity · 2023Article
- Oxidative Stress and the Pathophysiology and Symptom Profile of Schizophrenia Spectrum Disorders.Frontiers in psychiatry · 2021Review
- Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.International journal of molecular sciences · 2019Review
- Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders: aNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Fearful dogs have increased plasma glutamine and γ-glutamyl glutamine.Scientific reports · 2018Article
- Mapping the Schizophrenia Genes by Neuroimaging: The Opportunities and the Challenges.International journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe proton magnetic resonance spectroscopy (
methods
resultsGlx levels in GM positively correlated with glutamate-related genetic risk score but only in younger (≤36 years) schizophrenia patients (
conclusionElevations in brain Glx are in part, related to common allelic variants of glutamate-related genes known to increase the risk for schizophrenia. Since the glutamate risk scores did not differ between groups, some other genetic or environmental factors likely interact with the variability in glutamate-related risk SNPs to contribute to an increase in brain Glx early in the illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.