Evidence map›Paper›PMID 28659788›Full record

ReviewFrontiers in aging neuroscience2017

Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation.

Assenza Giovanni, Fioravante Capone, Lazzaro di Biase, Florinda Ferreri, Lucia Florio, Andrea Guerra, Massimo Marano, Matteo Paolucci, Federico Ranieri, Gaetano Salomone and 3 more

Erratum issuedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  8. Criticality and increased intrinsic neural timescales in stroke.NPJ systems biology and applications · 2025
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  20. Bioelectromagnetism in Human Brain Research: New Applications, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 4 countries.

Assenza GiovanniClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Fioravante CaponeClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Lazzaro di BiaseClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Florinda FerreriClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Lucia FlorioClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Andrea GuerraClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Massimo MaranoClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Matteo PaolucciClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Federico RanieriClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Gaetano SalomoneClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Mario TombiniClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Gregor ThutCentre for Cognitive Neuroimaging (CCNi), Institute of Neuroscience and Psychology, University of GlasgowGlasgow, United Kingdom.
Vincenzo Di LazzaroClinical Neurology, Campus Biomedico University of RomeRome, Italy.
Università Campus Bio-Medico · ITWellcome Centre for Human Neuroimaging · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-invasive brain stimulation (NIBS) has been under investigation as adjunct treatment of various neurological disorders with variable success. One challenge is the limited knowledge on what would be effective neuronal targets for an intervention, combined with limited knowledge on the neuronal mechanisms of NIBS. Motivated on the one hand by recent evidence that oscillatory activities in neural systems play a role in orchestrating brain functions and dysfunctions, in particular those of neurological disorders specific of elderly patients, and on the other hand that NIBS techniques may be used to interact with these brain oscillations in a controlled way, we here explore the potential of modulating brain oscillations as an effective strategy for clinical NIBS interventions. We first review the evidence for abnormal oscillatory profiles to be associated with a range of neurological disorders of elderly (e.g., Parkinson's disease (PD), Alzheimer's disease (AD), stroke, epilepsy), and for these signals of abnormal network activity to normalize with treatment, and/or to be predictive of disease progression or recovery. We then ask the question to what extent existing NIBS protocols have been tailored to interact with these oscillations and possibly associated dysfunctions. Our review shows that, despite evidence for both reliable neurophysiological markers of specific oscillatory dis-functionalities in neurological disorders and NIBS protocols potentially able to interact with them, there are few applications of NIBS aiming to explore clinical outcomes of this interaction. Our review article aims to point out oscillatory markers of neurological, which are also suitable targets for modification by NIBS, in order to facilitate in future studies the matching of technical application to clinical targets.

Indexed as

EEGneuromodulationnon-invasive brain stimulationoscillationsTMS/tDCS

Identifiers

PMID28659788
PMCPMC5468377
OpenAlexW2625013945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.