ArticleFrontiers in aging neuroscience2017
Better Correlation of Cognitive Function to White Matter Integrity than to Blood Supply in Subjects with Leukoaraiosis.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Multimodal MRI markers of white matter hyperintensities and their impact on cognition in cerebral small vessel disease: a systematic review.Brain imaging and behavior · 2026Pooled it
- Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Cerebral small vessel disease score associated with brain hypoperfusion predicts cognitive decline: a longitudinal study.BMC medical imaging · 2025Article
- Activation of glutamatergic neurons in the somatosensory cortex promotes remyelination in ischemic vascular dementia.Fundamental research · 2024Article
- Evidence of An Association Between Cerebral Blood Flow and Microstructural Integrity in Normative Aging Using a Holistic MRI Approach.Journal of magnetic resonance imaging : JMRI · 2023Article
- Clinical and cognitive correlates tractography analysis in patients with white matter hyperintensity of vascular origin.Frontiers in neuroscience · 2023Article
- Association of Cerebral Blood Flow With Longitudinal Changes in Cerebral Microstructural Integrity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.JAMA network open · 2022Article
- The Diagnostic Value of the Combined 3D Pseudo-Continuous Arterial Spin Labeling and Diffusion Kurtosis Imaging in Patients With Binswanger's Disease.Frontiers in neuroscience · 2022Article
- Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment.Frontiers in neurology · 2022Review
- Application of 3D-ASL in hemodynamic analysis and prognosis evaluation of vascular cognitive impairment.American journal of translational research · 2022Article
- The relationship between diabetes-related cognitive dysfunction and leukoaraiosis.Acta neurologica Belgica · 2021Review
- Contribution of Inflammation and Hypoperfusion to White Matter Hyperintensities-Related Cognitive Impairment.Frontiers in neurology · 2021Article
- Leukoaraiosis Mediates the Association of Total White Blood Cell Count With Post-Stroke Cognitive Impairment.Frontiers in neurology · 2021Article
- Corpus callosum integrity loss predicts cognitive impairment in Leukoaraiosis.Annals of clinical and translational neurology · 2020Article
- Discriminating VCID subgroups: A diffusion MRI multi-model fusion approach.Journal of neuroscience methods · 2020Review
- Association of cerebral blood flow with myelin content in cognitively unimpaired adults.BMJ neurology open · 2020Article
- Assessment of cerebrovascular reserve impairment using the breath-holding index in patients with leukoaraiosis.Neural regeneration research · 2019Article
- Leukoaraiosis Predicts Short-term Cognitive But not Motor Recovery in Ischemic Stroke Patients During Rehabilitation.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Observational
- Innovative MRI Techniques in Neuroimaging Approaches for Cerebrovascular Diseases and Vascular Cognitive Impairment.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukoaraiosis is associated with increased risk of cognitive impairment, but its pathophysiological pathway is unclear. The aim of the present study was to determine whether brain structural damage or cerebral blood supply better correlated with the global cognitive outcome in subjects with leukoaraiosis. Seventy-five subjects with leukoaraiosis were included in present study, with age ranged from 43 to 85 years, with mean white matter hyperintensities (WMH) volume 30.69 ± 24.35 mL. Among them, 19(25.33%) subjects presented with cerebral microbleeds (CMB) and 40 (53.33%) subjects presented with lacunes. These participants received arterial spin labeling perfusion MRI, diffusion-tensor imaging (DTI) and diffusion Kurtosis imaging. We analyzed the cerebral blood flow (CBF) by dividing the brain tissue into three regions: WMH, normal appearing white matter (NAWM) and cortex. After adjusting for age and gender, the CBF of NAWM was significantly correlated with fractional anisotropy (FA) (
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Registered trials
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