ArticleFrontiers in computational neuroscience2017
Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function.
Article in Frontiers in computational neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 421 citations in OpenAlex.
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- Electrophysiological classification of human layer 2-3 pyramidal neurons reveals subtype-specific synaptic interactions.Nature neuroscience · 2026Article
- Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation).eLife · 2026Article
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- Enhanced information processing in the human neocortex: cellular mechanisms and translational perspectives.Frontiers in synaptic neuroscience · 2026Review
- Gridography tractography reveals communication between key areas from global workspace and integrated information theories of consciousness.Scientific reports · 2025Article
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- Of mice and men: Dendritic architecture differentiates human from mouse neuronal networks.iScience · 2025Article
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- Topological Neuroscience: Linking Circuits to Function.Annual review of neuroscience · 2025Review
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- Heterogeneous and higher-order cortical connectivity undergirds efficient, robust, and reliable neural codes.iScience · 2025Article
- Persistent Topological Laplacians-A Survey.Mathematics (Basel, Switzerland) · 2025Article
- Biological detail and graph structure in network neuroscience.Frontiers in network physiology · 2025Review
- Specific inhibition and disinhibition in the higher-order structure of a cortical connectome.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Long Journey from Animal Electricity to the Discovery of Ion Channels and the Modelling of the Human Brain.Biomolecules · 2024Review
- Cortical cell assemblies and their underlying connectivity: An in silico study.PLoS computational biology · 2024Article
- Neural Geometrodynamics, Complexity, and Plasticity: A Psychedelics Perspective.Entropy (Basel, Switzerland) · 2024Article
- The impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study.Network neuroscience (Cambridge, Mass.) · 2024Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lack of a formal link between neural network structure and its emergent function has hampered our understanding of how the brain processes information. We have now come closer to describing such a link by taking the direction of synaptic transmission into account, constructing graphs of a network that reflect the direction of information flow, and analyzing these directed graphs using algebraic topology. Applying this approach to a local network of neurons in the neocortex revealed a remarkably intricate and previously unseen topology of synaptic connectivity. The synaptic network contains an abundance of cliques of neurons bound into cavities that guide the emergence of correlated activity. In response to stimuli, correlated activity binds synaptically connected neurons into functional cliques and cavities that evolve in a stereotypical sequence toward peak complexity. We propose that the brain processes stimuli by forming increasingly complex functional cliques and cavities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.