Evidence map›Paper›PMID 28659769›Full record

ArticleFrontiers in systems neuroscience2017

Propofol, Sevoflurane, and Ketamine Induce a Reversible Increase in Delta-Gamma and Theta-Gamma Phase-Amplitude Coupling in Frontal Cortex of Rat.

Dinesh Pal, Brian H Silverstein, Lana Sharba, Duan Li, Viviane S Hambrecht-Wiedbusch, Anthony G Hudetz, George A Mashour

Open access · goldAbstract read
In one paragraph

Article in Frontiers in systems neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dinesh PalDepartment of Anesthesiology, University of MichiganAnn Arbor, MI, United States.
Brian H SilversteinCenter for Consciousness Science, University of MichiganAnn Arbor, MI, United States.
Lana SharbaDepartment of Anesthesiology, University of MichiganAnn Arbor, MI, United States.
Duan LiDepartment of Anesthesiology, University of MichiganAnn Arbor, MI, United States.
Viviane S Hambrecht-WiedbuschDepartment of Anesthesiology, University of MichiganAnn Arbor, MI, United States.
Anthony G HudetzDepartment of Anesthesiology, University of MichiganAnn Arbor, MI, United States.
George A MashourDepartment of Anesthesiology, University of MichiganAnn Arbor, MI, United States.
University of Michigan–Ann Arbor · US

Funding

VOLATILE ANESTHETICS AND CEREBRAL BLOOD FLOW REGULATIONR01GM056398 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUDETZ, ANTHONY GEORGE · 1997 to 2024
$6.9M
Neuroimaging of Anesthetic Modulation of Human ConsciousnessR01GM103894 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Zirui Huang, Anthony George Hudetz · 2013 to 2026
$4.0M
NIGMS NIH HHS R01 GM056398NIGMS NIH HHS R01 GM103894
6 · The paper itself

Abstract

Studies from human and non-human species have demonstrated a breakdown of functional corticocortical connectivity during general anesthesia induced by anesthetics with diverse molecular, neurophysiological, and pharmacological profiles. Recent studies have demonstrated that changes in long-range neural communication, and by corollary, functional connectivity, might be influenced by cross-frequency coupling (CFC) between the phase of slow oscillations and the amplitude of local fast oscillations. Phase-amplitude coupling (PAC) between slow oscillations and alpha rhythm during general anesthesia reveal distinct patterns depending on the anesthetic. In this study, we analyzed the effect of three clinically used anesthetics (propofol:

Indexed as

anesthesiaketaminephase-amplitude couplingpower spectrumpropofolsevoflurane

Identifiers

PMID28659769
PMCPMC5468385
OpenAlexW2687814776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.