Evidence map›Paper›PMID 28659724›Full record

ArticleCurrent genomics2017

Identification of Sets of Cytoskeletal Related and Adhesion-related Coding Region Mutations in the TCGA Melanoma Dataset that Correlate with a Negative Outcome.

John M Yavorski, Rebecca J Stoll, Mohammad D Samy, James A Mauro, George Blanck

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

John M Yavorski1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA; 2Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Rebecca J Stoll1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA; 2Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Mohammad D Samy1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA; 2Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
James A Mauro1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA; 2Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
George Blanck1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA; 2Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
University of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRelatively little cancer genome atlas data has been associated with clinically relevant stratifications of individual cancers.

resultsMutations in two subsets of a cytoskeletal related and adhesion-related protein coding region set (CAPCRs) were determined to have strong associations with a negative outcome for melanoma, in-cluding a subset constituted by: DSCAM, FAT3, MUC17 and PCDHGC5 (p < 0.0001).

conclusionRoles for CAPCR mutations in cancer progression raise a question about the potential dominant negative impact of these mutations for multi-meric subcellular and extra-cellular protein struc-tures.

Indexed as

Cancer genome atlasCytoskeletal and cell-adhesion genomicsExtra-cellular matrixMelanoma metastasisMelanoma stratification

Identifiers

PMID28659724
PMCPMC5476947
OpenAlexW2605795058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.