Evidence map›Paper›PMID 28659646›Full record

ArticleIsrael journal of chemistry2017

Synthesis of the Right-Side Structure of Type B Physalins.

Masaki Morita, Shuntaro Kojima, Megumi Ohkubo, Hiroyuki Koshino, Daisuke Hashizume, Go Hirai, Keiji Maruoka, Mikiko Sodeoka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Israel journal of chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Natural Products fromMolecules (Basel, Switzerland) · 2022
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masaki MoritaSynthetic Organic Chemistry Laboratory RIKEN2-1 Hirosawa Wako Saitama 351-0198 Japan.
Shuntaro KojimaSynthetic Organic Chemistry Laboratory RIKEN2-1 Hirosawa Wako Saitama 351-0198 Japan.
Megumi OhkuboSynthetic Organic Chemistry Laboratory RIKEN2-1 Hirosawa Wako Saitama 351-0198 Japan.
Hiroyuki KoshinoSynthetic Organic Chemistry Laboratory RIKEN2-1 Hirosawa Wako Saitama 351-0198 Japan.
Daisuke HashizumeRIKEN Center for Emergent Matter Science2-1 Hirosawa Wako Saitama 351-0198 Japan.
Go HiraiSynthetic Organic Chemistry Laboratory RIKEN2-1 Hirosawa Wako Saitama 351-0198 Japan.
Keiji MaruokaDepartment of Chemistry Graduate School of Science Kyoto University Sakyo Kyoto 606-8502 Japan.
Mikiko SodeokaSynthetic Organic Chemistry Laboratory RIKEN2-1 Hirosawa Wako Saitama 351-0198 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a full account of our synthetic studies on the racemic DEFGH-ring moiety of physalins, featuring domino ring transformation of a tricyclic key intermediate. We also report the results of a detailed mechanistic examination of the domino ring transformation, as well as a reoptimization of the 2,3-Wittig rearrangement and methylation steps. Furthermore, we have newly established a method for the preparation of an optically active synthetic intermediate by enzymatic kinetic resolution. Our work provides access to both natural and nonnatural right-side physalin structures.

Indexed as

domino reactionsnatural productsoptical resolutionphysalinssteroids

Identifiers

PMID28659646
PMCPMC5467525

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.